Results 71 to 80 of about 191,094 (249)

Decoy DNA protects molecular tension probes from DNase degradation

Angewandte Chemie International Edition, Accepted Article.
DNA‐based molecular probes are essential tools for visualizing and quantifying mechanotransduction at the single‐molecule level. However, their application in live‐cell environments is severely limited by DNase‐mediated degradation, which shortens probe lifespan and introduces false‐positive signals.
Hongyuan Zhang, Seong Ho Kim, Isaac T.S. Li   +2 more
wiley   +1 more source

Mesoscopic irreversible thermodynamics of aging kinetics of alpha polypeptides [DNA] under various constraints: Special reference to the simple spring mechanics

AIP Advances
The mesoscopic irreversible thermodynamic treatment of α-polypeptides and the helical polynucleotides (DNA) furnishes two sets of analytical expressions, which allow us not only to analyze the reversible force–extension experiments performed by atomic ...
T. Ogurtani
semanticscholar   +1 more source

Controlling Assembly of Hybrid DNA Nanostructures into Higher‐Order Structures via Hydrophobicity

Angewandte Chemie International Edition, Accepted Article.
Hydrophobic interactions are one of the fundamental driving forces of self‐assembly in living systems. It remains challenging to harness hydrophobicity to have a controllable and programmable assembly of DNA nanostructures. On the other hand, there is also a need to explore orthogonal hierarchical assembly strategies to be used as an additional toolset
Minu Saji, Devanathan Perumal, Qi Yang, Frieder Jaekle, Fei Zhang   +4 more
wiley   +1 more source

The Iron‐Sulfur Cluster of Bacterioferritin‐Associated Ferredoxin (Bfd): A ‘Biological Fuse’ that Prevents Oxidative Damage to Cells?

Angewandte Chemie International Edition, Accepted Article.
Iron is in an essential micronutrient in living systems. However, it is also potentially toxic and so the concentration of chelatable iron within cells is tightly regulated to prevent catalytic formation of harmful reactive oxygen species (ROS). Ferritins play a key role in iron homeostasis by storing excess iron as an insoluble ferric mineral within ...
Justin M. Bradley, Aiden M. Carter, Zinnia Bugg, Simon C. Andrews, Nick Le Brun   +4 more
wiley   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Experimental Measurement of the Thermodynamics Underlying the Surface-Induced Structural Changes of Nucleic Acids and Proteins [PDF]

, 2016
Martin Kurnik, Netzahualcóyotl Arroyo, Hui Li, Di Kang, Kevin W. Plaxco   +4 more
openalex   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

New Trends in SERS Substrates With Micro‐ and Nanostructures: Materials, Substrates, Preparation, and Applications

Battery Energy, EarlyView.
In this review, the latest research progress in surface‐enhanced Raman scattering (SERS) is discussed comprehensively. It covers four main aspects of SERS technology: materials utilized, various types of SERS substrates, methods employed for their preparation, and recent applications explored in the field over the past few years.
Xiaoyu Tian, Bo Zhang, Lei Song, Jingwei Bao, Junsheng Yang, Liangbo Sun, Houchang Pei, Chunpeng Song   +7 more
wiley   +1 more source

The Azidofunctionalization of Alkenes

ChemistryEurope, EarlyView.
The azidofunctionalization of alkenes offers a powerful strategy for synthesizing nitrogen‐containing compounds by installing both an azide and a second functional group in one step. This approach, employing photoredox catalysis, transition metals, and radical methods, is efficient, selective, and versatile, with applications in pharmaceuticals and ...
Pierre Palamini, Jerome Waser
wiley   +1 more source