Results 131 to 140 of about 1,078,683 (343)

8-OXO-Cordycepin Is Not a Suitable Substrate for Adenosine Deaminase-Preliminary Experimental and Theoretical Studies

Molecules
Adenosine deaminase (ADA) is one of the most important enzymes in nucleoside metabolism, regulating the levels of adenosine and deoxyadenosine triphosphate (ADT/dATP) on either side of the cell membrane. This small protein (weighing approximately 40 kDa)
Boleslaw T. Karwowski
doaj   +1 more source

STUDIES IN HISTOCHEMISTRY: I. DETERMINATION OF NUCLEIC ACIDS IN MICROGRAM AMOUNTS OF TISSUE [PDF]

, 1956
Jesse F. Scott, ALBA P. FRACCASTORO, Edgar B. Taft   +2 more
openalex   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Organic Afterglow Materials for Tumor Diagnosis and Therapy

Biosensors
Organic afterglow nanoparticles (OANs) represent a unique class of optical materials capable of sustaining luminescence after excitation cessation.
Xiayi Chen, Bin Li, Baoli Yin, Dong Xu, Youjuan Wang   +4 more
doaj   +1 more source

Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics [PDF]

Nucleic Acids Research, 2018
Stoddard, Barry L., Khvorova, Anastasia, Corey, David R., Dynan, William S., Fox, Keith R.   +4 more
openaire   +4 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates

Signal Transduction and Targeted Therapy
Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyrosine kinase 7 (
Minhui Su, Yuan Liu, Hongxin Lin, Xiaoxing Wang, Danxia Ying, Lizhuan Zhang, Cai Yang, Mengyuan Jiang, Lujuan Xu, Xie Wang, Yang Sun, Haiyan Xu, Ziwen Zhang, Xiaojia Wang, Ting Fu, Sitao Xie, Jiaxuan He, Xiangsheng Liu, Weihong Tan   +18 more
doaj   +1 more source

Identifying Interaction Sites in "Recalcitrant" Proteins: Predicted Protein and Rna Binding Sites in Rev Proteins of Hiv-1 and Eiav Agree with Experimental Data [PDF]

, 2005
Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses.
Carpenter, Susan, Dobbs, Drena, Dobbs, Drena, Honavar, Vasant, Jernigan, Robert, Jernigan, Robert, Lee, Jae-Hyung, Terribilini, Michael, Yan, Changhui   +8 more
core   +3 more sources

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

Advanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong, Hyuna Kwak, Woojin Jeong, Hongwoo Lee, Su‐Ji Jeon, Hyo‐Jun Lee, Pil Joon Seo, Seon‐Yeong Kwak   +7 more
wiley   +1 more source