Results 111 to 120 of about 516,976 (317)

Advances in β-Thalassemia Gene Therapy: CRISPR/Cas Systems and Delivery Innovations

open access: yesCells
β-thalassemia is an inherited blood disorder caused by mutations in the β-globin (HBB) gene, leading to reduced or absent β-globin production, resulting in chronic anemia.
Hongmei Liu, Peng Zhang
doaj   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

open access: yesAdvanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park   +15 more
wiley   +1 more source

Nucleic Acid Delivery

open access: yesPharmaceutical Research, 2023
Lu, Zheng-Rong, Shi, Galen H.
openaire   +2 more sources

Erratum: Structure of the 70S ribosome from human pathogen Staphylococcus aureus (Nucleic Acids Research (2017) DOI: 10.1093/nar/gkw933) [PDF]

open access: yes, 2017
© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.The authors wish to correct their Funding statement as follows: FUNDING.
Bochler A.   +11 more
core  

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

open access: yesAdvanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk   +7 more
wiley   +1 more source

Nucleic acid enzymes: The fusion of self-assembly and conformational computing

open access: yes, 2009
Macromolecules are the predominant physical substrate sup-porting information processing in organisms. Two key characteristics—conformational dynamics and self-assembly properties—render macro-molecules unique in this context.
Zauner, K.-P., Ramlan, E. I.
core  

AI–Guided 4D Printing of Carnivorous Plants–Inspired Microneedles for Accelerated Wound Healing

open access: yesAdvanced Materials, EarlyView.
This work presents an artificial intelligence (AI)‐guided 4D‐printed microneedle platform inspired by carnivorous plants for wound healing. A thermo‐responsive shape memory polymer enables body temperature–triggered self‐coiling for autonomous wound closure.
Hyun Lee   +21 more
wiley   +1 more source

Delivery of Nucleic Acids [PDF]

open access: yesPharmaceutical Research, 2007
Mastrobattista, E.   +2 more
openaire   +3 more sources

Mass Spectrometric Characterization of Therapeutic Nucleic Acids

open access: yes, 2013
The power of high-resolution mass spectrometry for the investigation of higher-order nucleic acid structures and highly modified nucleic acids is demonstrated in the present study. Experiments on selected G-rich oligodeoxynucleotides including tetra-, bi-
Stucki, Silvan Remo
core  

Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine

open access: yesAdvanced Materials, EarlyView.
The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi   +2 more
wiley   +1 more source

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