Results 201 to 210 of about 449,751 (323)

Investigating the Potential for Label‐Free Detection of Cell Apoptosis through Terahertz Nano‐Metasurfaces

open access: yesAdvanced Photonics Research, EarlyView.
This study demonstrates a label‐free optical method to monitor cells using a terahertz metasurface‐based biosensing platform. The obtained terahertz signal change for the cell‐contained nanoslots before and after external stimulus is analyzed in terms of transmittance and frequency shift, dynamically representing the cell apoptosis process.
Yeeun Roh   +4 more
wiley   +1 more source

A Spectrophotometric Study on the Deoxypentose Nucleic Acid - Cysteine Reaction. [PDF]

open access: bronze, 1953
Sam Brody   +5 more
openalex   +1 more source

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

open access: yesAdvanced Therapeutics, EarlyView.
Antimicrobial resistance necessitates the development of new antibiotics with “resistance‐breaking” properties. In this study, conjugation of polycationic peptides is proven to represent a versatile strategy for the fast and affordable reactivation of daptomycin.
Sari Rasheed   +21 more
wiley   +1 more source

Structure-Guided design of Cas12a variants improves detection of nucleic acids. [PDF]

open access: yesCell Insight
Tong X   +5 more
europepmc   +1 more source

Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone

open access: yesAdvanced Therapeutics, EarlyView.
Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe   +6 more
wiley   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

open access: yesAdvanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe   +4 more
wiley   +1 more source

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation. [PDF]

open access: yesNat Commun
Hu T   +14 more
europepmc   +1 more source

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