Results 191 to 200 of about 465,053 (268)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Synthesis and RNA-Binding Properties of Heteroaryl Amino Pyridine Nucleobases for Triple-Helix-Forming Peptide Nucleic Acids. [PDF]

J Org Chem
Baskevics V, Farshineh Saei S, Kumpina I, Katkevica D, Ostrovska L, Rozners E, Katkevics M.   +6 more
europepmc   +1 more source

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, EarlyView.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source

Pathogen nucleic acids data in wastewater solids from 147 treatment plants in the United States: 2024-2025. [PDF]

Data Brief
Boehm AB, Wolfe MK, Bidwell AL, Zulli A, White BJ, Shelden B, Duong D.   +6 more
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The 2026 Nucleic Acids Research database issue and the online molecular biology database collection. [PDF]

Nucleic Acids Res
Rigden DJ, Fernández XM.
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next-Generation Diagnostics and Biosensing. [PDF]

Adv Sci (Weinh)
Nguyen JVL, Meziadi A, Brunner C, McKeague M, Malic L, Tabrizian M.   +5 more
europepmc   +1 more source

Amphiphilic Polymeric Micelle Spherical Nucleic Acids (SNAs) as Drug Delivery Vehicles. [PDF]

Bioconjug Chem
Cavaliere JP, Forsyth CM, Guo AX, Kang J, Ngo KH, Mirkin CA.   +5 more
europepmc   +1 more source

Host-Guest Assembly of Transmucosal Molecular Spherical Nucleic Acids for Oral Leukoplakia Immunotherapy and Microbiota Homeostasis Restoration. [PDF]

JACS Au
Xu Y, Zhao Z, Kong Y, Fan Y, He J, Fan Z, Wang G, Hu Y.   +7 more
europepmc   +1 more source

Nucleic acids in pleural fluid for the etiological diagnosis of pleural effusion. [PDF]

Transl Lung Cancer Res
Santotoribio JD, Dominguez-Garcia J.
europepmc   +1 more source