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Nucleic acids delivering nucleic acids
Advanced Drug Delivery Reviews, 2018Nucleic acid therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent innovative and highly promising molecules for the safe treatment of a wide range of pathologies. The efficiency of systemic treatments is impeded by 1) the need to overcome physical and functional barriers in the organism, and 2) to accumulate in the intracellular ...
Catuogno S +3 more
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Annual Review of Biochemistry, 1957
Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
W E, COHN, E, VOLKIN
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Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
W E, COHN, E, VOLKIN
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Acta Crystallographica Section D Biological Crystallography, 2002
The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
Helen M, Berman +5 more
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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
Helen M, Berman +5 more
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Journal of the American Chemical Society, 2012
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Joshua I, Cutler +2 more
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A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Joshua I, Cutler +2 more
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Current Opinion in Chemical Biology, 1999
Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
C, Carola, F, Eckstein
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Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
C, Carola, F, Eckstein
openaire +2 more sources