Results 291 to 300 of about 449,751 (323)
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Nucleic acids delivering nucleic acids
Advanced Drug Delivery Reviews, 2018Nucleic acid therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent innovative and highly promising molecules for the safe treatment of a wide range of pathologies. The efficiency of systemic treatments is impeded by 1) the need to overcome physical and functional barriers in the organism, and 2) to accumulate in the intracellular ...
Catuogno S +3 more
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Journal of the American Chemical Society, 2012
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
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A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
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Annual Review of Biochemistry, 1957
Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Acta Crystallographica Section D Biological Crystallography, 2002
The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
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Current Opinion in Biotechnology, 2005
Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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2017
Nucleic acids (NA) contain the genetic information and play a key role in protein biosynthesis. They are formed by the polymerization of units called nucleotides, which consist of a nitrogenous base, an aldopentose, and phosphoric acid. The base can be a pyrimidine: thymine (T), cytosine (C), and uracil (U); or a purine: adenine (A) and guanine (G ...
Antonio Blanco, Gustavo Blanco
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Nucleic acids (NA) contain the genetic information and play a key role in protein biosynthesis. They are formed by the polymerization of units called nucleotides, which consist of a nitrogenous base, an aldopentose, and phosphoric acid. The base can be a pyrimidine: thymine (T), cytosine (C), and uracil (U); or a purine: adenine (A) and guanine (G ...
Antonio Blanco, Gustavo Blanco
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Nature, 1952
Smith and Stoker1 have noted that the deoxyribonucleic acid of Q-fever rickettsiae (R. burneti) grown in embryonated eggs is closely similar in composition to that of chick embryos, the only significant difference being lack of 5-methyl cytosine from the former.
Seymour S. Cohen +2 more
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Smith and Stoker1 have noted that the deoxyribonucleic acid of Q-fever rickettsiae (R. burneti) grown in embryonated eggs is closely similar in composition to that of chick embryos, the only significant difference being lack of 5-methyl cytosine from the former.
Seymour S. Cohen +2 more
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1967
Publisher Summary Not only can antibodies against DNA be found in various autoimmune diseases, but DNA, RNA, various oligonucleotides, and even mono-nucleosides can be immunogenic under suitable conditions or when complexed with carriers such as methylated bovine serum albumin. This chapter reviews the development of the antigenicity of nucleic acids
Werner Braun, Otto J. Plescia
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Publisher Summary Not only can antibodies against DNA be found in various autoimmune diseases, but DNA, RNA, various oligonucleotides, and even mono-nucleosides can be immunogenic under suitable conditions or when complexed with carriers such as methylated bovine serum albumin. This chapter reviews the development of the antigenicity of nucleic acids
Werner Braun, Otto J. Plescia
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Current Opinion in Chemical Biology, 1999
Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
Fritz Eckstein, Christophe Carola
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Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
Fritz Eckstein, Christophe Carola
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2005
Saccharomyces cerevisiae is an excellent model organism for the study of eukaryotic genetics. Easy manipulation of yeast DNA is essential to its role in research, and studies of gene expression or regulation require analysis of RNA. This chapter presents quick and straightforward methods to isolate genomic DNA, plasmid DNA, or RNA from yeast.
Wei Xiao, Michelle Hanna
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Saccharomyces cerevisiae is an excellent model organism for the study of eukaryotic genetics. Easy manipulation of yeast DNA is essential to its role in research, and studies of gene expression or regulation require analysis of RNA. This chapter presents quick and straightforward methods to isolate genomic DNA, plasmid DNA, or RNA from yeast.
Wei Xiao, Michelle Hanna
openaire +3 more sources