Results 291 to 300 of about 1,103,498 (342)

The 23rd annual Nucleic Acids Research Web Server Issue 2025. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges. [PDF]

J Nanobiotechnology
Sanadgol N, Abedi M, Hashemzaei M, Kamran Z, Khalseh R, Beyer C, Voelz C.   +6 more
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Gold-Mediated Base Pairs in Nucleic Acids: Selective Coordination to Natural and Thiocarbonyl-Modified Cytosines Dependent upon the Oxidation State of Gold. [PDF]

Chembiochem
Kosugi K, Sugawara A, Iwase E, Park H, Fujiwara S, Kanazawa H, Ono A, Kondo J.   +7 more
europepmc   +1 more source

ReAlign-N: an integrated realignment approach for multiple nucleic acid sequence alignment, combining global and local realignments

Yixiao Zhai, Tong Zhou, Yanming Wei, Quan Zou, Yansu Wang   +4 more
openalex   +1 more source

Nucleic Acid Nanocapsules as a New Platform to Deliver Therapeutic Nucleic Acids for Gene Regulation. [PDF]

Acc Chem Res
Pal S, Cannata JN, Rouge JL.
europepmc   +1 more source

Aptamer-Mediated Covalent Dual Lysosome-Targeting Chimeras Enhance Targeted Degradation of Cell Surface Proteins

JACS Au
Tao Peng, Min Su, Zuying Zhang, Ya Wang, Yingdi Zhu, Juan Li   +5 more
doaj   +1 more source

Streamlined extraction of nucleic acids and metabolites from low- and high-biomass samples using isopropanol and matrix tubes. [PDF]

Microbiol Spectr
Brennan C, Shaffer JP, Belda-Ferre P, Mohanty I, Weng Y, Cantrell K, Ackermann G, Allaband C, Bryant M, Farmer S, González A, McDonald D, Martino C, Meehan MJ, Rahman G, Salido RA, Schwartz T, Song SJ, Tribelhorn C, Tubb HM, Dorrestein PC, Knight R.   +21 more
europepmc   +1 more source