Results 271 to 280 of about 1,085,302 (363)

Nucleic acids and protein synthesizing mechanisms of mitochondria. Progress report

, 1974
Yoshitaka Suyama
openalex   +2 more sources

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Breath biopsy biomarkers: cell-free nucleic acids in exhaled breath condensate. [PDF]

Front Med (Lausanne)
Pös O, Styk J, Kubanova M, Bokorova S, Buglyo G, Soltesz B, Lukasz P, Benes V, Repiska V, Nagy B, Szemes T.   +10 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids. [PDF]

Mol Ther Methods Clin Dev
Atmuri NDP, Saadati F, Kulkarni J, Witzigmann D, Cullis PR, Ciufolini MA.   +5 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Chiral Matching between Nucleic Acids and Polypeptides Facilitates Liquid-Liquid Phase Separation. [PDF]

J Phys Chem Lett
Pokhrel P, Zhang Z, Ji J, Shakya S, Jenyk J, Lower A, Janssen M, Mao H.   +7 more
europepmc   +1 more source

Nucleic Acids Res.

, 2011
Mann, M., Wisniewski, J., Zougman, A.
core  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A workflow to define structural classes and classify nucleic acids circular dichroism spectra. [PDF]

QRB Discov
Mosca K, Hoffmann SV, Grangier A, Wien F, Arluison V, Marco S.   +5 more
europepmc   +1 more source