Results 291 to 300 of about 1,085,302 (363)

Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids. [PDF]

Front Immunol
Welsh EJ, McCluskey D, Baum P, Lewis MJ, Capon F.   +4 more
europepmc   +1 more source

Characterization of multispecies biofilms by peptide nucleic acid fluorescence in situ hybridization (PNA-FISH)

, 2010
Carina Almeida, M. J. Vieira, C. W. Keevil, Rosa Maria Castilhos Fernandes, Nuno F. Azevedo   +4 more
openalex   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Interaction of Nanomaterials with Nucleic Acids and Their Applications in Nucleic Acid Analysis. [PDF]

Int J Biol Sci
Wang J, Li K, Li F, Li X, Zhou J, Yang M, Zhang X, Wang M, Li L.   +8 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Opening new frontiers with catalytic nucleic acids in miRNA inhibition. [PDF]

Front Pharmacol
Patutina O, Miroshnichenko S, Chiglintseva D, Zenkova M.   +3 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Scaling the RNA Summit: Reflections on the 2026 OPT congress

Molecular Therapy: Nucleic Acids
Paloma H. Giangrande
doaj   +1 more source

Development of Synthetic Routes to 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine. [PDF]

Chemistry
Kumagai R, Yamada R, Yamaguchi T, Obika S.   +3 more
europepmc   +1 more source

Antibacterial activities of novel peptide nucleic acids targeting <i>Salmonella</i> penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
El-Fateh M, Viau C, Ahmed N, Xia J, Zhao X.   +4 more
europepmc   +1 more source