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Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids. [PDF]
Mol Ther Methods Clin DevAtmuri NDP +5 more
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Science China Chemistry, 2020 Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis ...
Yongxi Zhao, Xiaolei Zuo, Qian Li
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Nucleic acids delivering nucleic acids
Advanced Drug Delivery Reviews, 2018Nucleic acid therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent innovative and highly promising molecules for the safe treatment of a wide range of pathologies. The efficiency of systemic treatments is impeded by 1) the need to overcome physical and functional barriers in the organism, and 2) to accumulate in the intracellular ...
Catuogno S +3 more
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Annual Review of Biochemistry, 1957
Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
W E, COHN, E, VOLKIN
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Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
W E, COHN, E, VOLKIN
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Journal of the American Chemical Society, 2012
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Joshua I, Cutler +2 more
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A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Joshua I, Cutler +2 more
openaire +2 more sources
Acta Crystallographica Section D Biological Crystallography, 2002
The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
Helen M, Berman +5 more
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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
Helen M, Berman +5 more
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Current Opinion in Chemical Biology, 1999
Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
C, Carola, F, Eckstein
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Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however.
C, Carola, F, Eckstein
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Nature, 1952
Smith and Stoker1 have noted that the deoxyribonucleic acid of Q-fever rickettsiae (R. burneti) grown in embryonated eggs is closely similar in composition to that of chick embryos, the only significant difference being lack of 5-methyl cytosine from the former.
G R, WYATT, S S, COHEN
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Smith and Stoker1 have noted that the deoxyribonucleic acid of Q-fever rickettsiae (R. burneti) grown in embryonated eggs is closely similar in composition to that of chick embryos, the only significant difference being lack of 5-methyl cytosine from the former.
G R, WYATT, S S, COHEN
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