Structure-Based Deep Mining Reveals First-Time Annotations for 46 Percent of the Dark Annotation Space of the 9,671-Member Superproteome of the Nucleocytoplasmic Large DNA Viruses. [PDF]
J Virol, 2020 We extended the known annotation space for the NCLDV by 46%, revealing high-probability structural matches for fully 45% of the 9,671 query proteins and confirming up to 98% of existing annotations per virus. The most prevalent protein families included ankyrin repeat- and MORN repeat-containing proteins, many of which included an F-box, suggesting ...
Mirzakhanyan Y, Gershon PD.
europepmc +4 more sources
Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms. [PDF]
Evol Bioinform Online, 2015 Recent research on genome evolution of large DNA viruses has highlighted a number of incredibly dynamic processes that can facilitate rapid adaptation. The genomes of amphibian-like ranaviruses - double-stranded DNA viruses infecting amphibians, reptiles, and fish (family Iridoviridae) - were examined to assess variation in genome content and ...
Price SJ.
europepmc +7 more sources
Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure. [PDF]
Microbiol Mol Biol Rev, 2017 SUMMARY The past 17 years have been marked by a revolution in our understanding of cellular multisubunit DNA-dependent RNA polymerases (MSDDRPs) at the structural level. A parallel development over the past 15 years has been the emerging story of the giant viruses, which encode MSDDRPs.
Mirzakhanyan Y, Gershon PD.
europepmc +6 more sources
Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses. [PDF]
J Virol, 2010 ABSTRACT Nucleocytoplasmic large DNA viruses (NCLDVs) are characterized by large genomes that often encode proteins not commonly found in viruses. Two species in this group are Acanthocystis turfacea chlorella virus 1 (ATCV-1) (family Phycodnaviridae , genus Chlorovirus
Parakkottil Chothi M +8 more
europepmc +5 more sources
Revisiting the early event of African swine fever virus DNA replication [PDF]
Journal of VirologyAs a member of nucleocytoplasmic large DNA viruses, African swine fever virus (ASFV) has been proposed to include an intriguing nuclear stage for DNA replication.
Wenlian Weng +12 more
doaj +2 more sources
iScience, 2021 Summary: In terms of genome and particle sizes, viruses exhibit great diversity. With the discovery of several nucleocytoplasmic large DNA viruses (NCLDVs) and jumbo phages, the relationship between particle and genome sizes has emerged as an important ...
Harshali V. Chaudhari +2 more
doaj +1 more source
Phylogenetic and phyletic studies of informational genes in genomes highlight existence of a 4 domain of life including giant viruses. [PDF]
PLoS ONE, 2010 The discovery of Mimivirus, with its very large genome content, made it possible to identify genes common to the three domains of life (Eukarya, Bacteria and Archaea) and to generate controversial phylogenomic trees congruent with that of ribosomal genes,
Mickaël Boyer +4 more
doaj +1 more source
The Viral Fraction Metatranscriptomes of Lake Baikal
Microorganisms, 2022 This article characterises viral fraction metatranscriptomes (smaller than 0.2 µm) from the pelagic zone of oligotrophic Lake Baikal (Russia). The study revealed the dominance of transcripts of DNA viruses: bacteriophages and algal viruses. We identified
Sergey Potapov +5 more
doaj +1 more source
Classification and Determination of Possible Origins of ORFans through Analysis of Nucleocytoplasmic Large DNA Viruses [PDF]
Intervirology, 2010 <i>Objective:</i> An important proportion of coding sequences in genomes, notably in viruses, do not match any sequences in databases and are assigned as ORFan sequences. Nucleocytoplasmic large DNA viruses (NCLDVs) harbor great numbers of ORFs with a high number consisting of ORFans. Thus, we decided to decipher the nature of ORFans in the
Mickaël, Boyer +3 more
openaire +2 more sources
Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses
Nature Communications, 2020 Nucleocytoplasmic large DNA viruses (NCLDV) exhibit a large genomic repertoire and complex evolutionary history. Here, the authors generate 501 metagenome-assembled genomes from diverse environments and show NCLDVs to harbor a wide range of potential ...
Mohammad Moniruzzaman +3 more
doaj +1 more source