Results 61 to 70 of about 3,301 (121)

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Poxvirus Host Range Genes and Virus–Host Spectrum: A Critical Review

Viruses, 2017
The Poxviridae family is comprised of double-stranded DNA viruses belonging to nucleocytoplasmic large DNA viruses (NCLDV). Among the NCLDV, poxviruses exhibit the widest known host range, which is likely observed because this viral family has been more ...
Graziele Pereira Oliveira, Rodrigo Araújo Lima Rodrigues, Maurício Teixeira Lima, Betânia Paiva Drumond, Jônatas Santos Abrahão   +4 more
doaj   +1 more source

Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
A high‐throughput direct infusion mass spectrometry platform, enabled by gas‐phase ion mobility separation, supports single‐injection analysis of peptides, polar metabolites, and lipids. Coupled with custom software, it identified ∽1,300 proteins and ∽600 metabolites in ∽4.3 minutes per sample, and demonstrated broad utility in macrophage polarization ...
Yuming Jiang, Ivan Salladay‐Perez, Amanda Momenzadeh, Jesús Muñoz‐Estrada, Uktarsh Tripathi, Anthony J. Covarrubias, Jesse G. Meyer   +6 more
wiley   +1 more source

The genome of the brown alga Ectocarpus siliculosus contains a series of viral DNA pieces, suggesting an ancient association with large dsDNA viruses

BMC Evolutionary Biology, 2008
Background Ectocarpus siliculosus virus-1 (EsV-1) is a lysogenic dsDNA virus belonging to the super family of nucleocytoplasmic large DNA viruses (NCLDV) that infect Ectocarpus siliculosus, a marine filamentous brown alga. Previous studies indicated that
Boland Wilhelm, Delaroque Nicolas
doaj   +1 more source

Metagenomic Characterization of the Viral Community of the South Scotia Ridge

Viruses, 2019
Viruses are the most abundant biological entities in aquatic ecosystems and harbor an enormous amount of genetic diversity. Whereas their influence on marine ecosystems is widely acknowledged, current information about their diversity remains limited. We
Qingwei Yang, Chen Gao, Yong Jiang, Min Wang, Xinhao Zhou, Hongbing Shao, Zheng Gong, Andrew McMinn   +7 more
doaj   +1 more source

Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone

Nature Communications
The organization of DNA into nucleosomes is a ubiquitous and ancestral feature that was once thought to be exclusive to the eukaryotic domain of life. Intriguingly, several representatives of the Nucleocytoplasmic Large DNA Viruses (NCLDV) encode histone-
Chelsea M. Toner, Nicole M. Hoitsma, Sashi Weerawarana, Karolin Luger   +3 more
doaj   +1 more source

Putative Promoter Motif Analyses Reinforce the Evolutionary Relationships Among Faustoviruses, Kaumoebavirus, and Asfarvirus

Frontiers in Microbiology, 2018
Putative promoter motifs have been described in viruses belonging to the nucleocytoplasmic large DNA viruses (NCLDVs) group; however, few studies have been conducted to search for promoter sequences in newly discovered amoebal giant viruses.
Graziele P. Oliveira, Isabella L. M. de Aquino, Ana P. M. F. Luiz, Jônatas S. Abrahão   +3 more
doaj   +1 more source

Viral Diversity and Its Relationship With Environmental Factors at the Surface and Deep Sea of Prydz Bay, Antarctica

Frontiers in Microbiology, 2018
A viral metagenomic analysis of five surface and two bottom water (878 meters below surface, mbs, and 3,357 mbs) samples from Prydz Bay, was conducted during February–March 2015.
Zheng Gong, Yantao Liang, Yantao Liang, Min Wang, Min Wang, Min Wang, Yong Jiang, Yong Jiang, Yong Jiang, Qingwei Yang, Jun Xia, Xinhao Zhou, Siyuan You, Chen Gao, Jian Wang, Jianfeng He, Hongbing Shao, Andrew McMinn, Andrew McMinn   +18 more
doaj   +1 more source

Viral outbreak in corals associated with an in situ bleaching event: atypical herpes-like viruses and a new megavirus infecting Symbiodinium

Frontiers in Microbiology, 2016
Previous studies of coral viruses have employed either microscopy or metagenomics, but few have attempted to comprehensively link the presence of a virus-like particle (VLP) to a genomic sequence. We conducted transmission electron microscopy imaging and
Adrienne M.S. Correa, Adrienne M.S. Correa, Tracy D. Ainsworth, Stephanie M. Rosales, Andrew R. Thurber, Christopher R. Butler, Christopher R. Butler, Rebecca Lisette Vega Thurber   +7 more
doaj   +1 more source

Hypermethylated genome of a fish vertebrate iridovirus ISKNV plays important roles in viral infection

Communications Biology
Iridoviruses are nucleocytoplasmic large dsDNA viruses that infect invertebrates and ectothermic vertebrates. The hypermethylated genome of vertebrate iridoviruses is unique among animal viruses.
Mincong Liang, Weiqiang Pan, Yanlin You, Xiaowei Qin, Hualong Su, Zhipeng Zhan, Shaoping Weng, Changjun Guo, Jianguo He   +8 more
doaj   +1 more source