A nuclear localization signal binding protein in the nucleolus. [PDF]
U. Thomas Meier, Günter Blobel
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TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler+20 more
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Nucleolar beacon for monitoring nucleolar morphology and proteomics in living cells. [PDF]
Gao J+9 more
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Cytogenetics of bisexual/unisexual species of Poecilia. VI. Additional nucleolus organizer region chromosomal clones of Poecilia formosa (Amazon molly) from Texas, with a survey of chromosomal clones detected in the Amazon molly [PDF]
LUCIANA SOLA+3 more
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Transcription‐coupled repair: tangled up in convoluted repair
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher+3 more
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Mechanisms of ribosomopathy and phase separation-related ribosomopathy. [PDF]
Pan Z+5 more
europepmc +1 more source
Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups.
A. de Capoa+4 more
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Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component [PDF]
Ian R. Kill
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Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley +1 more source
Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments. [PDF]
Cheng HH+5 more
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