Results 201 to 210 of about 79,372 (334)

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

open access: yesThe FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler   +20 more
wiley   +1 more source

Nucleolar beacon for monitoring nucleolar morphology and proteomics in living cells. [PDF]

open access: yesSci Adv
Gao J   +9 more
europepmc   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

open access: yesThe FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher   +3 more
wiley   +1 more source

Mechanisms of ribosomopathy and phase separation-related ribosomopathy. [PDF]

open access: yesJ Zhejiang Univ Sci B
Pan Z   +5 more
europepmc   +1 more source

Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups.

open access: bronze, 1982
A. de Capoa   +4 more
openalex   +1 more source

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

open access: yesThe FEBS Journal, EarlyView.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source

Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments. [PDF]

open access: yesProc Natl Acad Sci U S A
Cheng HH   +5 more
europepmc   +1 more source

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