Results 81 to 90 of about 72,696 (188)
rDNA Copy Number Variation and Methylation During Normal and Premature Aging
Aging Cell, Volume 24, Issue 5, May 2025.In > 160 healthy individuals the absolute rDNA copy number (CN) in blood ranged from approximately 240 to 900. The number of active copies with a completely unmethylated promoter varied from 40 to 120, independent of absolute CN. Promoter methylation is a compensation mechanism for absolute CN variation. Aging was associated with a loss of unmethylated
Alva B. C. Geisen +5 more
wiley +1 more source
Aging Cell, Volume 24, Issue 5, May 2025.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence
Aging Cell, Volume 24, Issue 4, April 2025.Senescence inducing stimuli leads to large‐cluster hypercondensed DNA globules. This architectural phenomenon is associated with geographically clustered transcriptional repression. Such large‐scale clustered silencing of chromosomal segments may drive deep senescence through two possible ways: (1) one or more critical combination of genes, for example
Aditi U. Gurkar +4 more
wiley +1 more source
Andrology, EarlyView.Abstract Background Testicular tumors are among the most frequently diagnosed cancers in young men. The consequences of this diagnosis are orchiectomies, severely restricting fertility. For these young patients, a comprehensive diagnostics would be desirable, achieving a refined diagnosis and improved therapeutic patient stratification.
Diana Pinkert‐Leetsch +6 more
wiley +1 more source
Andrology, EarlyView.Abstract Background WFS1 spectrum disorder, also known as Wolfram syndrome (WS) is an ultra‐rare (<1:500,000; ORPHA: 3463) monogenic (OMIM #222300) progressive neuroendocrine and neurodegenerative disorder, characterised by early‐onset insulin‐dependent diabetes, optic atrophy, central diabetes insipidus and sensi‐neuronal deafness.
Julia Rohayem +6 more
wiley +1 more source
Brain Pathology, Volume 35, Issue 3, May 2025.In progressive MS, mixed active plaques and perivascular inflammation in the sub/juxtacortical white matter correlate with similar (albeit fainter) pathologies in the cortical parenchyma Abstract It remains elusive whether lesions and inflammation in the sub/juxtacortical white matter reflect cortical and/or meningeal pathologies.
Betül Okutan +10 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez +17 more
wiley +1 more source
Cancer Science, EarlyView.Our study reveals that hypoxia inhibitors ameliorate iodine uptake dysfunction in thyroid cancer by acting on the hsa_circ_0023990/miR‐448/DNMT1/NIS signaling pathway. ABSTRACT This research seeks to investigate how hypoxia inhibitors enhance iodine uptake in thyroid cancer cells. Clinical samples were gathered and assessed for hsa_circ_0023990, DNMT1,
Ruiqin Gou +5 more
wiley +1 more source
HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity
Cell Proliferation, EarlyView.HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman +4 more
wiley +1 more source
Advances in the Study of Pluripotent Stem Cells in Livestock
Cell Proliferation, EarlyView.Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou +6 more
wiley +1 more source