Results 1 to 10 of about 27,766 (218)

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor [PDF]

BMC Biology, 2021
Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. Results We constructed loss-of-function mutants of NDPK-D, lacking either
Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon, Jérôme Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Thérond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bièche, Uwe Schlattner, Mathieu Boissan   +28 more
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Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA damage responses [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND NME23/NDPKs are well conserved proteins found in all living organisms. In addition to being nucleoside diphosphate kinases (NDPK), they are multifunctional enzymes involved in different processes such as DNA stability, gene regulation and DNA
Chantal Reigada, Melisa Sayé, Fabio Di Girolamo, Edward A Valera-Vera, Claudio A Pereira, Mariana R Miranda   +5 more
doaj   +2 more sources

A phosphohistidine phosphatase promotes starvation survival by dephosphorylating nucleoside diphosphate kinase [PDF]

Cell Reports
Summary: Nucleoside diphosphate kinase (Ndk) is a ubiquitous enzyme that maintains the cellular nucleoside triphosphate (NTP) pool and participates in many other pathways of eukaryotes and prokaryotes.
Akash R. Sinha, Mark Goulian
doaj   +2 more sources

Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis [PDF]

Frontiers in Immunology, 2020
Schistosomiasis, caused by Schistosoma mansoni trematode worm, affects more than 1.5 million people in Brazil. The current treatment consists in the administration of Praziquantel, the only medicine used for treatment for more than 40 years.
Túlio di Orlando Cagnazzo, Camila Tita Nogueira, Cynthia Aparecida de Castro, Débora Meira Neris, Ana Carolina Maragno Fattori, Ricardo de Oliveira Correia, Yulli Roxenne Albuquerque, Bruna Dias de Lima Fragelli, Tiago Manuel Fernandes Mendes, Silmara Marques Allegretti, Edson Garcia Soares, Larissa Romanello, Juliana Roberta Torini, Humberto D’Muniz Pereira, Fernanda de Freitas Anibal   +14 more
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Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H+ leak [PDF]

Pharmaceutical Biology, 2023
Context The toxicity of atractyloside/carboxyatractyloside is generally well recognized and commonly ascribed to the inhibition of mitochondrial ADP/ATP carriers, which are pivotal for oxidative phosphorylation.
Andrzej M. Woyda-Ploszczyca
doaj   +2 more sources

General and specific promotion of flagellar assembly by a flagellar nucleoside diphosphate kinase. [PDF]

Mol Biol Cell, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Zhu X, Poghosyan E, Gopal R, Liu Y, Ciruelas KS, Maizy Y, Diener DR, King SM, Ishikawa T, Yang P.   +9 more
europepmc   +3 more sources

A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure [PDF]

Nanomaterials, 2018
During a heart failure, an increased content and activity of nucleoside diphosphate kinase (NDPK) in the sarcolemmal membrane is responsible for suppressing the formation of the second messenger cyclic adenosine monophosphate (cAMP)—a key component ...
Anushka Ray, Isaac Macwan, Shrishti Singh, Sushila Silwal, Prabir Patra   +4 more
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Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2013
Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing.
Florian Georgescauld, Lucile Moynié, Johann Habersetzer, Laura Cervoni, Iulia Mocan, Tudor Borza, Pernile Harris, Alain Dautant, Ioan Lascu   +8 more
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Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei. [PDF]

PLoS ONE, 2017
Nucleoside diphosphate kinase (NDK), which has the same sequence as oncoprotein (OP) in humans, can induce nucleoside triphosphates in DNA replication by maintenance of the deoxynucleotide triphosphate (dNTP's) and is known to be regulated by viral ...
Peng-Fei Liu, Qing-Hui Liu, Yin Wu, Jie Huang   +3 more
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An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase function [PDF]

Journal of Bacteriology
MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any residue. Major MutT proteins hydrolyze 8-oxo-(d)GTP (8-oxo-GTP or 8-oxo-dGTP) to the corresponding 8-oxo-
Elhassan Ali Fathi Emam, Koyel Roy, Devendra Pratap Singh, Deepak K. Saini, Umesh Varshney   +4 more
doaj   +2 more sources