Results 101 to 110 of about 27,766 (218)

Mitochondrial NME6: A Paradigm Change within the NME/NDP Kinase Protein Family?

Cells
Eukaryotic NMEs/NDP kinases are a family of 10 multifunctional proteins that occur in different cellular compartments and interact with various cellular components (proteins, membranes, and DNA).
Bastien Proust, Maja Herak Bosnar, Helena Ćetković, Malgorzata Tokarska-Schlattner, Uwe Schlattner   +4 more
doaj   +1 more source

Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis

Cellular Physiology and Biochemistry, 2013
Background: A growing body of evidence implicates novel roles for nm23-like proteins in the regulation of cellular functions. However, roles of these proteins in islet function and glucose-stimulated insulin secretion (GSIS) remain largely unknown ...
Rajakrishnan Veluthakal, David Kaetzel, Anjaneyulu Kowluru   +2 more
doaj   +1 more source

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans [PDF]

, 2013
The group I members of the Nm23 (non-metastatic) gene family encode nucleoside diphosphate kinases (NDPKs) that have been implicated in the regulation of cell migration, proliferation and differentiation.
Abdus-Saboor, Andolfo, Biggs, Bilitou, Burdine, Cui, Dammai, Deplagne, Desvignes, Eisenmann, Hartsough, Harłozińska, Heimann, Hippe, Hippe, Hofmann, Hurd, Igawa, Inoue, Kokel, Kolch, Kornfeld, Lee, Mocan, Mochizuki, Müller, Nicholas, Ohmachi, O’Connell, Rochdi, Salerno, Sieburth, Steeg, Steeg, Sundaram, Sundaram, Szewczyk, Takadate, Tso, Wagner, Yochem, Yoder   +41 more
core   +2 more sources

MoRgs3 functions in intracellular reactive oxygen species perception-integrated cAMP signaling to promote appressorium formation in Magnaporthe oryzae

mBio
Regulator of G-protein signaling (RGS) proteins exhibit GTPase-accelerating protein activities to govern G-protein function. In the rice blast fungus Magnaporthe oryzae, there is a family of at least eight RGS and RGS-like proteins (MoRgs1 to MoRgs8 ...
Ruiming Zhang, Xinyu Liu, Jiayun Xu, Chen Chen, Zhaoxuan Tang, Chengtong Wu, Xinyue Li, Lei Su, Muxing Liu, Leiyun Yang, Gang Li, Haifeng Zhang, Ping Wang, Zhengguang Zhang   +13 more
doaj   +1 more source

NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis.

PLoS ONE, 2015
Gastric cancer is one of the most common malignancies and has a high rate of metastasis. We hypothesize that NME2 (Nucleoside Diphosphate Kinase 2), which has previously been considered as an anti-metastatic gene, plays a role in the invasiveness of ...
Yan-fei Liu, Aijun Yang, Wei Liu, Chenyu Wang, Min Wang, Lihan Zhang, Dongcang Wang, Jing-fei Dong, Min Li   +8 more
doaj   +1 more source

Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]

, 2003
Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles, Freeman, Nicola V. E., Newby, Andrew C., Sala-Newby, Graciela B.   +3 more
core   +1 more source

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]

, 2008
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W., Bollinger, J. Martin, Jr., Brown, Daniel M., Cameron, Craig E., Edathil, Jocelyn P., Galarraga, Jessica E., Graci, Jason D., Harki, Daniel A., Loakes, David, Peterson, Blake R., Smidansky, Eric D., Too, Kathleen   +11 more
core   +4 more sources

Receptor Activation Regulates Cortical, but not Vesicular Localization of NDP Kinase [PDF]

, 2003
We used immunofluorescence techniques to determine the localization of nucleoside diphosphate (NDP) kinase in NIH-3T3 fibroblasts. We found that cytoplasmic NDP kinase can be separated into two populations according to subcellular localization and ...
Gallagher, Betty C., Mitchell, Kimberly A.P., Otero, Angela de S., Szabo, Gabor   +3 more
core   +1 more source

Nucleoside-diphosphate kinase of uropathogenic Escherichia coli inhibits caspase-1-dependent pyroptosis facilitating urinary tract infection

Cell Reports
Summary: Uropathogenic Escherichia coli (UPEC) is the most common causative agent of urinary tract infection (UTI). UPEC invades bladder epithelial cells (BECs) via fusiform vesicles, escapes into the cytosol, and establishes biofilm-like intracellular ...
Xueping Li, Jiarui Zhou, Xingmei Liu, Chen Jin, Le Liu, Hongmin Sun, Qian Wang, Qiushi Wang, Ruiying Liu, Xiaoyu Zheng, Yutao Liu, Yu Pang   +11 more
doaj   +1 more source