Results 111 to 120 of about 27,766 (218)

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

PLoS ONE, 2012
Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell   +4 more
doaj   +1 more source

Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. [PDF]

, 2016
RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.
Chong, Jenny, Huang, Xuhui, Hwang, Candy S, Kool, Eric T, McKenna, Charles E, Shin, Ji Hyun, Ulrich, Sébastien, Wang, Dong, Wang, Wei, Xu, Liang, Zhang, Lu   +10 more
core   +3 more sources

Analysis of a Streptomyces coelicolor A3(2) locus containing the nucleoside diphosphate kinase (ndk) and folylpolyglutamate synthetase (folC) genes [PDF]

, 2017
A 3.6-kb DNA fragment from Streptomyces coelicolor A3(2) with the genes valS probably encoding a valyl-tRNA synthetase, folC encoding folylpolyglutamate synthetase, and ndk encoding a nucleoside diphosphate kinase was analysed. folC and ndk are separated
Brandt, Birgit, Burger, Annette, Süsstrunk, Urs, Thompson, Charles J., Wohlleben, Wolfgang   +4 more
core  

Analysis of Erysipelothrix rhusiopathiae and Erysipelothrix tonsillarum by multilocus enzyme electrophoresis [PDF]

, 1994
The genetic diversity of 74 Australian field isolates of Erysipelothrix rhusiopathiae and 22 reference strains for serovars of E. rhusiopathiae or Erysipelothrix tonsillarum was examined by multilocus enzyme electrophoresis.
Chooromoney, K.N., Hampson, D.J., Eamens, G.J., Turner, M.J.   +3 more
core   +1 more source

Nucleoside Diphosphate Kinase [PDF]

Journal of Biological Chemistry, 1996
Anna Karlsson, Sébastien Mesnildrey, Yingwu Xu, Solange Moréra, Joël Janin, Michel Véron   +5 more
openaire   +1 more source

Gaining molecular insights towards inhibition of foodborne fungi Aspergillus fumigatus by a food colourant violacein via computational approach

Scientific Reports
Filamentous Fungal Human Pathogens (FFHPs) such as Aspergillus fumigatus, are growing resistant to currently available antifungal drugs. One possible target, the Nucleoside diphosphate kinase (Ndk) is significant for nucleotide biosynthesis and crucial ...
R. Sindhu, Smitha S. Bhat, Jiraporn Sangta, Chandan Dharmashekar, Bhargav Shreevatsa, Chandan Shivamallu, Devananda Devegowda, Shiva Prasad Kollur, Sheikh F. Ahmad, Sabry M. Attia, Sarana Rose Sommano, Shashanka K. Prasad   +11 more
doaj   +1 more source

Method to express and purify nm23-H2 protein from baculovirus-infected cells

BioTechniques, 2003
High-throughput protein expression and purification are major bottlenecks in the postgenomic and proteomic era. We show here an automated method to express and purify nm23-H2, a nucleoside diphosphate kinase (NDPK), in a 96-well format, by the use of a ...
L. Garzia, A. André, A. Amoresano, A. D'Angelo, R. Martusciello, C. Cirulli, T. Tsurumi, G. Marino, M. Zollo   +8 more
doaj   +1 more source

Mycoplasmas and cancer [PDF]

, 2014
The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan, Liekens, Sandra, Vande Voorde, Johan   +2 more
core  

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +1 more source

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

eLife, 2016
KCa2.1, KCa2.2, KCa2.3 and KCa3.1 constitute a family of mammalian small- to intermediate-conductance potassium channels that are activated by calcium-calmodulin.
Shekhar Srivastava, Saswati Panda, Zhai Li, Stephen R Fuhs, Tony Hunter, Dennis J Thiele, Stevan R Hubbard, Edward Y Skolnik   +7 more
doaj   +1 more source