Results 11 to 20 of about 27,766 (218)

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A. [PDF]

PLoS ONE, 2016
Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent protein kinase A (PKA) and ATP-regulated chloride channel.
Lee A Borthwick, Mathieu Kerbiriou, Christopher J Taylor, Giorgio Cozza, Ioan Lascu, Edith H Postel, Diane Cassidy, Pascal Trouvé, Anil Mehta, Louise Robson, Richmond Muimo   +10 more
doaj   +9 more sources

Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction [PDF]

Cardiovascular Diabetology
Background Nucleoside diphosphate kinase B (NDPKB) deficiency in endothelial cells (ECs) promotes the activation of the hexosamine biosynthesis pathway (HBP), leading to vascular damage in the retina.
Feng Shao, Johanna Wieland, Yixin Wang, Merve Keles, Zenghui Meng, Santosh Lomada, Miao Qin, Veronika Leiss, Abel Martin-Garrido, Manuela Fuhrmann, Yi Qiu, Felix A. Trogisch, Christiane Vettel, Joerg Heineke, Yuxi Feng   +14 more
doaj   +2 more sources

Structural and Functional Analyses of Trypanosoma brucei Nucleoside Diphosphate Kinase [PDF]

ACS Omega
Patricia Makori, Michael P. Boeckman, Heidi S. David, Finley Payne, Markenya Gatling, Colby Greer, Dylan Hayes, Alexandra Jefferson, Micaela Maxwell, Christian Smith, Jamilah Watson, London Williams, Jazmin Barkley, Caitlyn Pepper, Tawanda Zininga, Sandhya Subramanian, Ariel Abramov, Anna S. Gardberg, Thomas E. Edwards, Bart L. Staker, Lance J. Stewart, Peter J. Myler, Oluwatoyin A Asojo, Olamide Jeje, Sylvia Fanucchi, Ikechukwu Achilonu, Craig L. Smith, Graham Chakafana   +27 more
doaj   +2 more sources

Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy [PDF]

Frontiers in Pharmacology
PurposeWhile great progress has been made in screening methods and therapies for proliferative diabetic retinopathy (PDR), it is still a major cause of blindness.
Andrew Gregory, Ahmed M. Awad, Ahmed M. Awad, Ahmed M. Awad, Shaimaa Eltanani, Thangal Yumnamcha, Jenna Hart, Rao Me, Xihui Lin, Mohamed Shawky, Mohamed Shawky, Ahmed S. Ibrahim, Ahmed S. Ibrahim, Ahmed S. Ibrahim, Ahmed S. Ibrahim   +14 more
doaj   +2 more sources

Revisiting trypanosomatid nucleoside diphosphate kinases [PDF]

Memórias do Instituto Oswaldo Cruz, 2021
An increasing amount of research has led to the positioning of nucleoside diphosphate kinases (NDPK/NDK) as key metabolic enzymes among all organisms. They contribute to the maintenance the intracellular di- and tri- phosphate nucleoside homeostasis, but they also are involved in widely diverse processes such as gene regulation, apoptosis, signal ...
Mariana R Miranda, Melisa Sayé, Chantal Reigada, Facundo Galceran, Marcos Rengifo, Belen J Maciel, Fabio A Digirolamo, Claudio A Pereira   +7 more
openaire   +4 more sources

Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of Chlamydomonas to Ionizing Radiation

Frontiers in Plant Science, 2021
The enzyme phosphoribosyl pyrophosphate synthase (PRPS) catalyzes the conversion of ribose 5-phosphate into phosphoribosyl diphosphate; the latter is a precursor of purine and pyrimidine nucleotides.
Sera Jung, Sera Jung, Kwang Min Koo, Jaihyunk Ryu, Inwoo Baek, Soon-Jae Kwon, Jin-Baek Kim, Joon-Woo Ahn   +7 more
doaj   +1 more source

Correction: Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction [PDF]

Cardiovascular Diabetology
Feng Shao, Johanna Wieland, Yixin Wang, Merve Keles, Zenghui Meng, Santosh Lomada, Miao Qin, Veronika Leiss, Abel Martin-Garrido, Manuela Fuhrmann, Yi Qiu, Felix A. Trogisch, Christiane Vettel, Joerg Heineke, Yuxi Feng   +14 more
doaj   +2 more sources

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]

, 2020
International ...
Boissan, Mathieu, Farkas, Zsolt, Kopper, László, Mehta, Anil, Mátyási, Barbara, Sebestyén, Anna, Takács-Vellai, Krisztina   +6 more
core   +4 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A

Redox Biology, 2021
The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells.
Bess Yi Kun Yu, Maria-Armineh Tossounian, Stefan Denchev Hristov, Ryan Lawrence, Pallavi Arora, Yugo Tsuchiya, Sew Yeu Peak-Chew, Valeriy Filonenko, Sally Oxenford, Richard Angell, Jerome Gouge, Mark Skehel, Ivan Gout   +12 more
doaj   +1 more source