Results 51 to 60 of about 27,766 (218)

The Targeting of the atToc159 Preprotein Receptor to the Chloroplast Outer Membrane is Mediated by its GTPase Domain and is Regulated by GTP [PDF]

, 2002
The multimeric translocon at the outer envelope membrane of chloroplasts (Toc) initiates the recognition and import of nuclear-encoded preproteins into chloroplasts.
Hiltbrunner, Andreas, Kessler, Felix, Schnell, Danny J., Smith, Matthew D.   +3 more
core   +2 more sources

Cytosolic Trypanosoma cruzi nucleoside diphosphate kinase generates large granules that depend on its quaternary structure [PDF]

, 2014
Nucleoside diphosphate kinase (NDPK) is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and has been shown to play important roles in many cellular processes.
Di Girolamo, Fabio Augusto, Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal   +4 more
core   +1 more source

Brucella abortus BspJ Is a Nucleomodulin That Inhibits Macrophage Apoptosis and Promotes Intracellular Survival of Brucella

Frontiers in Microbiology, 2020
To date, a variety of Brucella effector proteins have been found to mediate host cell secretion, autophagy, inflammation, and other signal pathways, but nuclear effector proteins have not yet been reported. We identified the first Brucella nucleomodulin,
Zhongchen Ma, Zhongchen Ma, Zhongchen Ma, Ruirui Li, Ruirui Li, Ruirui Li, Ruirui Hu, Xiaoyu Deng, Xiaoyu Deng, Xiaoyu Deng, Yimei Xu, Wei Zheng, Wei Zheng, Wei Zheng, Jihai Yi, Jihai Yi, Jihai Yi, Yong Wang, Yong Wang, Yong Wang, Chuangfu Chen, Chuangfu Chen, Chuangfu Chen   +22 more
doaj   +1 more source

Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]

, 2015
We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert, Ingle, Shakti, Tullius, Tom   +2 more
core   +3 more sources

STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5

iScience, 2020
Summary: Loss of midbrain dopaminergic (mDA) neurons and their axons is central to Parkinson's disease (PD). Growth differentiation factor (GDF)5 is a potential neurotrophic factor for PD therapy.
Jayanth Anantha, Susan R. Goulding, Sean L. Wyatt, Ruth M. Concannon, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe   +6 more
doaj   +1 more source

Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. [PDF]

, 2011
Caveolae are flask-shaped invaginations in the plasma membrane that serve to compartmentalize and organize signal transduction processes, including signals mediated by G protein-coupled receptors and heterotrimeric G proteins.
H.A. Katus, H.J. Hippe, I. Abu-Taha, N.M. Wolf, S. Just, S. Le Lay, S. Lutz, T. Wieland, W. Rottbauer   +8 more
core   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides

Small Structures
Two convergent approaches for synthesizing a new class of nucleoside diphosphate prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides comprise an acyloxybenzyl group in combination with a lipophilic alkyl residue at ...
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson’s disease

ADMET and DMPK, 2020
Parkinson’s disease (PD) is a progressive neurodegenerative disease. Levodopa in combination with amantadine has a demonstrated efficacy in motility impairment. An extensive investigation of some enzymes described to be upregulated or downregulated in PD
Mihaela Ileana Ionescu
doaj   +1 more source