Results 61 to 70 of about 27,766 (218)
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1 [PDF]
, 2002 Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious.
Du, J., Hannon, G. J.
core +1 more source
Autophosphorylation of nucleoside diphosphate kinase from Myxococcus xanthus [PDF]
Journal of Bacteriology, 1993 The nucleoside diphosphate kinase (NDP kinase) from Myxococcus xanthus has been purified to homogeneity and crystallized (J. Munoz-Dorado, M. Inouye, and S. Inouye, J. Biol. Chem. 265:2702-2706, 1990). In the presence of ATP, the NDP kinase was autophosphorylated.
J, Muñoz-Dorado +3 more
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter +10 more
wiley +1 more source
, 2018 Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
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Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study [PDF]
, 2012 Objective: Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for standard dosing is controversial.
Chen, Jianmeng +7 more
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Advanced NanoBiomed Research, EarlyView.Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling
Life Science AllianceResearchers discover that NME7, a lesser studied protein, is required for cilium assembly and Hedgehog signaling, impacting ciliary microtubule stability. This study advances our understanding of primary cilium assembly and functions.
Menghui Ji +7 more
doaj +1 more source
Micro, 2022 Nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane is crucial for the synthesis of cyclic adenosine monophosphate (cAMP) to maintain the calcium ion balance.
Andrey Zaznaev, Isaac Macwan
doaj +1 more source
Salvage enzymes in nucleotide biosynthesis [PDF]
, 2007 Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core
Nucleoside diphosphate kinase/Nm23 and Epstein–Barr virus [PDF]
Molecular and Cellular Biochemistry, 2009 Nm23-H1 was discovered as the first metastasis suppressor gene about 20 years ago. Since then, extensive work has contributed to understanding its role in various cellular signaling pathways. Its association with a range of human cancers as well as its ability to regulate cell cycle and suppress metastasis has been explored. We have determined that the
Masanao, Murakami +3 more
openaire +2 more sources