Results 91 to 100 of about 173,532 (309)

An Expeditious Total Synthesis of 5′-Deoxy-toyocamycin and 5′-Deoxysangivamycin

Molecules, 2019
In present paper, an expeditious total synthesis of naturally occurring 5′-deoxytoyocamycin and 5′-deoxysangivamycin was accomplished. Because of the introduction of a benzoyl group at N-6 of 4-amino-5-cyano-6-bromo-pyrrolo[2,3-d]pyrimidine ...
Xiangyou Dong, Jie Tang, Chen Hu, Jiang Bai, Haixin Ding, Qiang Xiao   +5 more
doaj   +1 more source

Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism

Molecules, 2020
Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, hamper their ...
Freideriki Michailidou, Tomas Lebl, Alexandra M. Z. Slawin, Sunil Vishnuprasadji Sharma, Murray J. B. Brown, Rebecca Jane Miriam Goss   +5 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

The distribution and diversity of nucleoside N-deoxyribosyltransferase among lactic acid bacteria [PDF]

Nucleoside N-deoxyribosyltransferases are capable of synthesising stereoand regioselectively a variety of 2'-deoxy- and 2', 3'-dideoxyribonucleosides.
Chawdhri, Rizwana F.
core  

New nucleoside analogues for the recognition of pyrimidine-purine inversion sites [PDF]

, 2003
A new nucleoside designed to enhance triplex stability has been synthesised in 15 steps starting from sugar 2. This pathway contains the sugar derivative 9 which is a useful intermediate for the introduction of other natural and unnatural bases into the ...
Leumann, Christian, Buchini, S.
core   +1 more source

BIẾN ĐỔI VÒNG ĐƯỜNG XYLOSE THÀNH CÁC CHẤT TRUNG GIAN CHO QUÁ TRÌNH TỔNG HỢP THUỐC TRỊ UNG THƯ, KHÁNG VIRUT HIV

Tạp chí Khoa học Đại học Cần Thơ, 2008
Xylose được biết đến như một trong những nguyên liệu đầu của việc tổng hợp thuốc trị bệnh ung thư, AIDS và một số bệnh khác.  Việc tổng hợp những dẫn xuất trung gian quan trọng để điều chế những thuốc này đã đạt được.
Trương Thị Minh Hải, Lê Thanh Phước   +1 more
doaj  

Chiral-Modified Nucleoside Analogues: From Bioactivity to Therapeutic Applications

Pharmaceuticals
Nucleosides are extensively employed for the development of pharmaceuticals, chemotherapeutic agents, and bioregulators. Background/Objectives: The introduction of an additional chiral functionality into a carbohydrate or heterocyclic base fragment may ...
Anna A. Kozlova, Valentina N. Borokh, Vladimir E. Oslovsky, Cyril S. Alexeev, Mikhail S. Drenichev   +4 more
doaj   +1 more source

Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5’-alkynylation

Beilstein Journal of Organic Chemistry, 2017
The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivities (65 ...
Raja Ben Othman, Mickaël J. Fer, Laurent Le Corre, Sandrine Calvet-Vitale, Christine Gravier-Pelletier   +4 more
doaj   +1 more source

Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5 Position

Chemosensors, 2015
Nucleic acids that change their properties upon photo-irradiation could be powerful materials for molecular sensing with high spatiotemporal resolution.
Shohei Mori, Kunihiko Morihiro, Yuuya Kasahara, Shin-ichi Tsunoda, Satoshi Obika   +4 more
doaj   +1 more source

New Chemical Probe Targeting Bacterial NAD Kinase

Molecules, 2020
Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways.
David A. Clément, Clarisse Leseigneur, Muriel Gelin, Dylan Coelho, Valérie Huteau, Corinne Lionne, Gilles Labesse, Olivier Dussurget, Sylvie Pochet   +8 more
doaj   +1 more source