Results 91 to 100 of about 149,829 (255)
Beilstein Journal of Organic Chemistry, 2018 To synthesize nucleoside and oligosaccharide derivatives, we often use a glycosylation reaction to form a glycoside bond. Coupling reactions between a nucleobase and a sugar donor in the former case, and the reaction between an acceptor and a sugar donor
Yuichi Yoshimura +4 more
doaj +1 more source
Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill
Beilstein Journal of Organic Chemistry, 2017 Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes.
Olga Eguaogie +8 more
doaj +1 more source
Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding
Molecules, 2017 Adenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3, which belong to the G protein-coupled receptor (GPCR) superfamily.
Antonella Ciancetta, Kenneth A. Jacobson
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association
Angewandte Chemie International Edition, EarlyView.We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Long‐acting intramuscular cabotegravir/rilpivirine (LA CAB/RPV) is contraindicated with rifampicin because of the risk of markedly reduced antiretroviral exposure, although clinical pharmacokinetic data for this interaction are lacking. We describe a 49‐year‐old man with virologically suppressed HIV‐1 infection receiving LA CAB/RPV every 8 weeks who ...
Emilie M. Gieling +6 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham +3 more
wiley +1 more source
From apex to base: Uncovering spatial metabolic adaptation in Antarctic mosses
Bulletin of the Korean Chemical Society, EarlyView.Antarctic mosses survive extreme cold, desiccation, UV exposure, and oxidative stress. We analyzed three species by separating apical, middle, and basal zones. Each zone showed distinct metabolite patterns and biological roles, revealing spatial metabolic specialization. The results suggest that whole‐plant survival depends on coordinated contributions
Fatima Tuz Zahra +7 more
wiley +1 more source
Stereochemical Control in the Matteson Reaction
Chemistry – A European Journal, EarlyView.The Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Hae Mo Lee, Christoph Hirschhäuser
wiley +1 more source