Results 91 to 100 of about 251,788 (307)
Beilstein Journal of Organic Chemistry, 2017 The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivities (65 ...
Raja Ben Othman +4 more
doaj +1 more source
Chemosensors, 2015 Nucleic acids that change their properties upon photo-irradiation could be powerful materials for molecular sensing with high spatiotemporal resolution.
Shohei Mori +4 more
doaj +1 more source
New Chemical Probe Targeting Bacterial NAD Kinase
Molecules, 2020 Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways.
David A. Clément +8 more
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Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]
, 2011 To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi +3 more
core +2 more sources
Tạp chí Khoa học Đại học Cần Thơ, 2008 Xylose được biết đến như một trong những nguyên liệu đầu của việc tổng hợp thuốc trị bệnh ung thư, AIDS và một số bệnh khác. Việc tổng hợp những dẫn xuất trung gian quan trọng để điều chế những thuốc này đã đạt được.
Trương Thị Minh Hải +1 more
doaj
Pharmaceuticals, 2011 The behavior of 2-ethoxy-(4H)-3,1-benzoxazin-4-one (1) towards nitrogen nucleo-philes, e.g. ethanolamine, aromatic amines (namely: p-toluidine, p-anisidine, p-hydroxyaniline, o-hydroxyaniline, o-bromoaniline, o-phenylenediamine, p-phenylene- diamine, o ...
Fakhry A. El-Bassiouny +3 more
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Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]
, 2013 BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry +39 more
core +3 more sources
Sensors, 2006 A new saccharides sensor based on the TTF-anthracene dyad with two boronicacid (2) groups was designed and synthesized. This new saccharides sensor showsselectivity towards D-glucose while its analogue with one boronic acid group (1) wasreported to bind ...
Daoben Zhu +3 more
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Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
core +2 more sources
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
core +1 more source