Results 81 to 90 of about 173,532 (309)
Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents
Molecules, 2020 Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies.
Mahesh Kasthuri +8 more
doaj +1 more source
Advanced Science, EarlyView.Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena +2 more
wiley +1 more source
The rate of viral rebound after attainment of an HIV load < 50 copies/mL according to specific antiretroviral drugs in use: Results from a multicenter cohort study [PDF]
, 2005 Background. Relatively few data are available on the association between the use of specific antiretroviral drugs and the rate of viral rebound in those attaining a viral load (VL) 500 copies/ mL).
Smith, CJ +16 more
core +1 more source
Angewandte Chemie, EarlyView.State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson +3 more
wiley +2 more sources
Synthesis of C-Arylnucleoside Analogues
Molecules, 2015 Modified nucleoside analogues are of great biological importance as antiviral and antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an aromatic ring in different positions of the glycone for their biological ...
Christophe Len, Gérald Enderlin
doaj +1 more source
Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
wiley +1 more source
The enzymatic synthesis of nucleoside analogues [PDF]
Ribavirin, 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum antiviral agent active against both DNA and RNA viruses. A range of 1,2,3-triazole, 1,2,4-triazole and benzotriazole analogues of ribavirin was synthesised using a crude ...
O'Connell, Grace Josephine
core
3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase [PDF]
Nucleoside analogue therapeutics have a proven capability within drug discovery as antimicrobial, antiviral and antineoplastic agents. However, their efficacy can be limited by poor cellular uptake, high off target toxicity and poor bioavailability ...
Aisling, Ní Cheallaigh +5 more
core +1 more source
Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLC-UV-MS [PDF]
, 2007 An HPLC-UV-MS method for simultaneous identification of predominant phenolics and minor nucleoside derivatives in Gastrodia elata was developed, which was based on their UV and MS characteristics summarized through a series of homemade reference standard
肖红斌 +4 more
core +1 more source
Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)
Beilstein Journal of Organic Chemistry, 2014 A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished.
Sabin Llona-Minguez, Simon P. Mackay
doaj +1 more source