Results 61 to 70 of about 149,829 (255)
Beilstein Journal of Organic ChemistryNucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the quick ...
Maksim V. Kvach +5 more
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Crystal structure of 8-(4-methylphenyl)-2′-deoxyadenosine hemihydrate
Acta Crystallographica Section E: Crystallographic Communications, 2018 In the asymmetric unit, equalling the unit cell (triclinic, P1, Z = 1), two molecules of the title compound, 8-(4-methylphenyl)-d-2′-deoxyadenosine, C17H19N5O3, are present, with distinct conformations of the two sugar moieties, together with one solvent
Ajaykumar V. Ardhapure +4 more
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Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang +6 more
wiley +2 more sources
Synthesis of C-Arylnucleoside Analogues
Molecules, 2015 Modified nucleoside analogues are of great biological importance as antiviral and antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an aromatic ring in different positions of the glycone for their biological ...
Christophe Len, Gérald Enderlin
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Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents
Molecules, 2020 Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies.
Mahesh Kasthuri +8 more
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Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids
Angewandte Chemie, EarlyView.Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi +3 more
wiley +2 more sources
Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)
Beilstein Journal of Organic Chemistry, 2014 A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished.
Sabin Llona-Minguez, Simon P. Mackay
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An Expeditious Total Synthesis of 5′-Deoxy-toyocamycin and 5′-Deoxysangivamycin
Molecules, 2019 In present paper, an expeditious total synthesis of naturally occurring 5′-deoxytoyocamycin and 5′-deoxysangivamycin was accomplished. Because of the introduction of a benzoyl group at N-6 of 4-amino-5-cyano-6-bromo-pyrrolo[2,3-d]pyrimidine ...
Xiangyou Dong +5 more
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