Predicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening [PDF]
arXiv, 2020 Global coronavirus disease pandemic (COVID-19) caused by newly identified SARS- CoV-2 coronavirus continues to claim the lives of thousands of people worldwide. The unavailability of specific medications to treat COVID-19 has led to drug repositioning efforts using various approaches, including computational analyses.
arxiv
Transport of F1-ATPase subunit β into mitochondria depends on both a membrane potential and nucleoside triphosphates [PDF]
, 1986 Transport of cytoplasmically synthesized precursor proteins into or across the inner mitochondrial membrane requires a mitochondrial membrane potential.
Bakker +35 more
core +1 more source
Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Angewandte Chemie International Edition, EarlyView.A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt +14 more
wiley +1 more source
Tạp chí Khoa học Đại học Cần Thơ, 2008 Xylose được biết đến như một trong những nguyên liệu đầu của việc tổng hợp thuốc trị bệnh ung thư, AIDS và một số bệnh khác. Việc tổng hợp những dẫn xuất trung gian quan trọng để điều chế những thuốc này đã đạt được.
Trương Thị Minh Hải +1 more
doaj
Preparation of 4 '-spirocyclobutyl nucleoside analogues as novel and versatile adenosine scaffolds
, 2019 Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4 '-spirocyclic adenosine analogues has received very little attention.
De Vleeschouwer, Freija +10 more
core +1 more source
Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]
, 2019 Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F. +4 more
core +1 more source
Ribozyme‐catalyzed site‐specific labeling of RNA using O6‐alkylguanine SNAP‐tag substrates
Angewandte Chemie International Edition, Accepted Article.Site‐specific modification of RNAs with functional handles enables studies of RNA structure, fate, function, and interactions. Ribozymes provide an elegant way to covalently modify an RNA of interest (ROI). Here, we report that the methyltransferase ribozyme MTR1 can be employed as a versatile tool for RNA modification and labeling.
Manisha B. Walunj +3 more
wiley +1 more source
RNA polymerase interactions and elongation rate [PDF]
arXiv, 2018 We show that non-steric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track determine strongly the kinetics of transcription elongation. With a focus on the role of collisions and cooperation, we introduce a stochastic model that allows for the exact analytical computation of the stationary ...
arxiv
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]
, 1987 Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]
, 2012 Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz +60 more
core +2 more sources