Results 121 to 130 of about 171,665 (294)

Aldehyde or Hydrate? Investigation into the Oxidation of 5‐Formylcytosine Derivatives Using a Computational and Experimental Approach

ChemBioChem, EarlyView.
Hydrate‐mediated oxidation of 5‐formyl nucleobases by the iron(IV)‐oxido complex proceeds via geminal diol intermediates, accelerating hydrogen‐atom transfer and revealing aza‐dependent kinetic and mechanistic pathways. This study investigates the oxidation of 5‐hydroxymethyl and 5‐formyl nucleobases using an iron(IV)‐oxido complex that mimics the ...
Kuangjie Liu, Annika Menke, Fabian L. Zott, Domenic Mayer, Lena J. Daumann, Hendrik Zipse   +5 more
wiley   +1 more source

THE DISSOCIATION CONSTANTS OF PLANT NUCLEOTIDES AND NUCLEOSIDES AND THEIR RELATION TO NUCLEIC ACID STRUCTURE

, 1925
P.A. Levene, Henry S. Simms
openalex   +1 more source

Model‐Based Optimization of Fed‐Batch In Vitro Transcription

ChemBioChem, EarlyView.
Using a mathematical model for the enzyme kinetics and solution thermodynamics of the in vitro transcription reaction, new optimized strategies are developed for fed‐batch transcription that can decrease the resource costs of mRNA synthesis while maintaining critical quality attributes for efficacy in vivo.
Nathan Merica Stover, Soroush Ahmadi, Jacob Rosenfeld, Francesco Destro, Allan S. Myerson, Richard D. Braatz   +5 more
wiley   +1 more source

SOME CHEMICAL PROPERTIES OF DESOXYRIBOSE NUCLEOSIDES

, 1951
Lionel A. Manson, J. O. Lampen
openalex   +1 more source

Ratiometric Detection of pH‐Induced i‐Motif Folding Based on a Dual Emissive Cytosine Analog

ChemBioChem, EarlyView.
A dual‐emissive cytosine analog enables ratiometric fluorescence detection of i‐motif DNA folding. This study reveals a sensitive method to monitor pH‐dependent i‐motif conformational changes, providing a valuable tool for investigating DNA secondary structures in vitro.
Nicolas P. F. Barthes, Hoang‐Ngoan Le, Benoît Y. Michel, Alain Burger   +3 more
wiley   +1 more source

Effect of Nucleosides on Acute Left Ventricular Failure in the Isolated Dog Heart

, 1959
N. M. Buckley, K.K. Tsuboi, Norman J. Zeig   +2 more
openalex   +1 more source

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

ChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

Synthesis and Incorporation of a pH‐Responsive Nucleoside Into DNA Sequences

ChemBioChem, EarlyView.
A pH‐responsive nucleoside is developed that enables a reversible switch in DNA between paired and unpaired states near physiological pH. This design may provide the framework for sequence‐independent, pH programable DNA motifs, thus paving the way for dynamic DNA nanotechnology applications.
Eric Ogel, Sidney Becker
wiley   +1 more source

Establishment, Characterization, and Cryopreservation of Feather Follicle Fibroblast Lines From Hyacinth Macaw (Anodorhynchus hyacinthinus)

Cell Biology International, EarlyView.
ABSTRACT Cryopreservation, biobanking, and in vitro propagation of cells from endangered species represent key strategies for advancing biodiversity conservation. The Hyacinth Macaw (Anodorhynchus hyacinthinus), a flagship avian species of the Brazilian Pantanal, is among the critically vulnerable taxa that stand to benefit significantly from such ...
Iara Pastor Martins Nogueira, Rachel Castro Teixeira‐Santos, Gustavo Caldeira Cotta, Wanderson Valente, John Lennon Paiva de Coimbra, Heloísa Athaydes Seabra Ferreira, Pedro Pires Goulart Guimarães, Anderson Kenedy Santos, Fernanda Mussi Fontoura, Kefany Rodrigues de Andrade Ramalho, Neiva Maria Robaldo Guedes, Samyra Maria dos Santos Nassif Lacerda   +11 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, EarlyView.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source