Results 161 to 170 of about 173,532 (309)

Long-term stability of RNA nucleoside standards for accurate LC-MS quantification. [PDF]

Nucleic Acids Res
Kerkhoff K, Wesseling H, Qi Y, Obersteiner S, Liu K, Berg M, Rusling L, Zipse H, Kaiser S.   +8 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues. [PDF]

ChemMedChem
Guillou A, Gros N, Muriaux D, Peyrottes S, Vasseur JJ, Smietana M, Mathé C.   +6 more
europepmc   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

Emerging roles of nucleoside transporters [PDF]

Since human Nucleoside Transporters (hNTs) were identified by their activity as transport systems, extensive work has been done to fully characterize them at the molecular and physiological level. Many efforts have been addressed to the identification of
Pastor Anglada, Marçal, Pérez Torras, Sandra   +1 more
core  

Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis. [PDF]

Int J Oral Sci
Li W, Wen Y, Huang Z, Shuai F, Yin Y, Chen Q, Zhu F, Xu H, Zhao H.   +8 more
europepmc   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Substrate Specificity of B12-Depedent Ribonucleotide Reductases: Biotechnology and Metabolic Implications. [PDF]

Chembiochem
Eltoukhy L, Loderer C.
europepmc   +1 more source

Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross‐Sectional Study Using Cardiac MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Antiretroviral therapy has transformed HIV into a chronic condition, yet cardiac injury remains a major issue. Purpose To assess the ability of cardiac MR imaging markers to predict cardiac injury and disease progression in HIV‐infected individuals. Study Type Prospective.
Chunyan Deng, Wei Sun, Tianhu Gao, Haixia Chen, Lu Liu, Ran Li   +5 more
wiley   +1 more source

Effects of mixed microbial fermentation on the quality and metabolite profile of cassava leaf feed based on untargeted metabolomics

JSFA reports, EarlyView.
Abstract Background Cassava leaves are a major byproduct of cassava processing and have a low utilization rate. In this study, Lactiplantibacillus plantarum, Saccharomyces cerevisiae, and Bacillus subtilis were used for solid‐state fermentation of cassava leaves to improve their feed quality. Results After 48 h of fermentation, the feed pH decreased to
Mengjun Zhou, Dongxiu Wang, jie Zhang, Jian Chen, Xuding Wen   +4 more
wiley   +1 more source