Results 161 to 170 of about 251,788 (307)

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Epigenetic Biomarkers for Predicting Nucleoside Analog Drug Response and Resistance in Cancer. [PDF]

Biomolecules
Kaszycki J, Lin JC, Kim M, Jung H.
europepmc   +1 more source

Emerging Agents for Boron Neutron Capture Therapy: Biomolecular Carriers Paving the Way for Precision Radiotherapy

Precision Radiation Oncology, EarlyView.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

NuConf: a rotamer library for DNA and RNA and its implementation in the protein design software MUMBO. [PDF]

Sci Rep
Makarova MO, Stiebritz MT, Basturk D, Lemke B, Süss B, Muller YA.   +5 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-experienced people with HIV-1: a systematic literature review and network meta-analysis. [PDF]

J Comp Eff Res
Curteis T, Eddowes LA, Karlsson A, Luedke H, Rubinstein M, Hempfling M, Gurney J, Gandhi-Patel B, Unger N, Mordi U, Chen M, Jarrett J, Sherman EM, Mounzer K, Khalsa AM, Dinges WL, McKellar MS, Lipps A.   +17 more
europepmc   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Small Molecule Inhibition of Mononegavirales RNA Polymerases. [PDF]

J Med Virol
Cao CR, Mohammed M, Yang G, Wang D.
europepmc   +1 more source

Phenotypic screening of a focused nucleoside library [PDF]

, 2016
Hulpia, Fabian, Van Calenbergh, Serge
core  

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source