Results 201 to 210 of about 286,275 (354)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Membrane-associated enzymes involved in nucleoside processing by plasma membrane vesicles isolated from L929 cells grown in defined medium.

, 1976
C C Li, Joy Hochstadt
openalex   +1 more source

Greener Biocatalytic Approach to the Synthesis of Nucleosides and their Precursors [PDF]

, 2008
Sunil K. Singh, Raman K. Sharma, Jyotirmoy Maity, Jesper Wengel, Virinder S. Parmar, Ashok K. Prasad   +5 more
openalex   +1 more source

MYC Addiction as a Targetable Vulnerability in Nelarabine‐Resistant T‐Cell Acute Lymphoblastic Leukemia

Cancer Science, EarlyView.
MYC drives nelarabine resistance in T‐ALL via a hyperactive transcriptional program. Pharmacological degradation of BET proteins dismantles this addiction, restoring drug sensitivity and extending survival in vivo. ABSTRACT Acquired resistance represents a fundamental obstacle limiting the long‐term efficacy of cancer chemotherapy.
Jingjing Gao, Chunxu Lin, Suchang Chen, Qi Mo, Chu Bao, Huali Deng, Ziyin Chen, Weichao Hao, Luyong Zhang, Min Wei   +9 more
wiley   +1 more source

Targeting <i>Plasmodium falciparum</i> with purine antimetabolites as a therapeutic strategy. [PDF]

Front Microbiol
Tashie W, de Koning HP, Duah-Quashie NO, Quashie NB.   +3 more
europepmc   +1 more source

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, EarlyView.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

Anti-Toxoplasma activity of NBMPR is mediated through the inhibition of nucleoside and nucleobase transporters. [PDF]

Parasitol Res
Pan M, Tang SQ, Ge CC, Fan SJ, He HX, Bian MM, Shen B, Huang SY.   +7 more
europepmc   +1 more source

Studies on sialic acids. IV Synthesis of N-acetyl-D-neuraminic acid N-nucleoside analogs.

, 1986
Haruo Ogura, HIDESHI FUJITA, Kimio Furuhata, Masayoshi Itoh, Yoshiyasu Shitori   +4 more
openalex   +2 more sources

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase

, 2021
Suliman Khan, Farnoosh Attar, Samir Haj Bloukh, Majid Sharifi, Faisal Nabi, Qian Bai, Rizwan Hasan Khan, Mojtaba Falahati   +7 more
openalex   +2 more sources