Results 191 to 200 of about 286,275 (354)

Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani, Katharina Remih, Anna Sophie Karl, Julia Alexandra Borchert, Christina Schrader, Malin Fromme, Can Kayatekin, Bailin Zhang, Mikhail Levit, Pavithra Krishnaswami, Louise E. van Eekeren, Leo A. B. Joosten, Twan Otten, Petra Tomanová, Pavel Strnad   +14 more
wiley   +1 more source

Metabolomics of Ocular Tissues with High and Low Metabolic Activity. [PDF]

Metabolites
Greiner JV, Glonek T.
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof-of-Concept Study. [PDF]

ChemMedChem
Lowe S, Satikuvar V, Syeda TM, Cal M, Mäser P, Kaiser M, Kadri H.   +6 more
europepmc   +1 more source

Efficacy and safety of novel russian non-nucleoside reverse transcriptase inhibitor elsulfavirine in combination with 2 nucleoside/nucleotide reverse transcriptase inhibitors in first-line HIV treatment – 96-week study

, 2018
А В Кравченко, Elena Orlova‐Morozova, Tatiana Shimonova, О. А. Козырев, Ф. И. Нагимова, Nataliya Zaharova, Э. С. Иванова, У. А. Куимова, А. А. Попова, Oksana Chernova, O. S. Tonkih, Д. А. Гусев, A. A. Yakovlev, Vadim Pokrovsky, Вадим В. Бычко, Natalia Vostokova   +15 more
openalex   +2 more sources

Novel Role of 3-Phosphoglycerate Kinase, a Glycolytic Enzyme, in the Activation of L-Nucleoside Analogs, a New Class of Anticancer and Antiviral Agents [PDF]

, 2003
Preethi Krishnan, Elizabeth A. Gullen, Wing Lam, Ginger E. Dutschman, Susan P. Grill, Yung‐Chi Cheng   +5 more
openalex   +1 more source

Nucleoside [PDF]

, 2020
openaire   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Enhancing the Nucleoside Analog Response with Translational Therapeutic Approaches to Overcome Resistance. [PDF]

Cells
Thibodeau J, Hershberger K, Ramakrishna SSM, Su Y, Timmer L, Brophy B, Zhang K, Edwards H, Taub JW, Ge Y.   +9 more
europepmc   +1 more source

A Deoxyribonuclease Which Requires Nucleoside Triphosphate from Micrococcus lysodeikticus

, 1970
Motoaki Anai, Takakata Hirahashi, Yasuyuki Takagi   +2 more
openalex   +1 more source