Results 231 to 240 of about 171,665 (294)

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys. [PDF]

Nat Commun
Pitts J, Zamora JLR, Manhas S, Aeschbacher T, Chan J, Cutillas V, Nair V, Riola NC, Vijjapurapu A, Vermillion MS, Eng S, Richards C, Han D, Perry JK, Chaudhuri S, Liu SW, Martinez C, Peinovich N, Sun KH, Cai A, Martin R, Moshiri J, Hedskog C, Babusis D, Siegel DS, Kalla R, Avadhanula V, Piedra PA, Stobbelaar K, Delputte PL, Marceau C, Mateo R, Maiorova E, Mo H, Subramanian R, Mackman RL, Cihlar T, Fletcher SP, Bilello JP.   +38 more
europepmc   +1 more source

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Left: Cells with active SAMHD1 can metabolize cytarabine (ara‐C) and fludarabine (F‐ara‐A) to their inactive precursors, limiting their cytotoxic effects. Right: Addition of hydroxyurea (hydroxycarbamide; HU) inhibits SAMHD1, leading to an increase in the active metabolites of ara‐C and F‐ara‐A and a subsequent increase in the cytotoxicity of these ...
Ingrid Lilienthal, Sijia Tao, Christer Nilsson, Elory Leonard, Runqing Zhang, Agnes L. Sorteberg, Louisa Fredrikson, Ioanna Xagoraris, Shahrzad Shirazi Fard, Nikolaos Tsesmetzis, Vasilios Zachariadis, Huan Cai, Lakshmi Sandhow, Anette Langebäck, Anna Bohlin, Katja Pokrovskaja Tamm, Sofia Bengtzén, Raymond F. Schinazi, Sören Lehmann, Baek Kim, Georgios Z. Rassidakis, Hong Qian, Martin Jädersten, Nikolas Herold   +23 more
wiley   +1 more source

UCK2-dependent conversion of cytidine to CTP is required for CTP uptake by <i>Chlamydia trachomatis</i>. [PDF]

MicroPubl Biol
Blanchet L, Subtil A.
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy. [PDF]

J Exp Clin Cancer Res
Vahabi M, Xu G, Sarkisjan D, Hassouni BE, Mantini G, Donati V, Wang B, Lencioni G, Honeywell RJ, Deng D, Strano S, Peters GJ, Blandino G, Giovannetti E.   +13 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Adsorption Tendency of Boron Oxide (B₂₄O₂₄) Nanocarrier toward Some Nucleobases and Their Nucleoside-Based Anticancer Drugs: A Comparative Density Functional Theory Study. [PDF]

ACS Omega
Rady ASM, Sidhom PA, Mohamed LA, Ibrahim KE, Khan S, Ibrahim MAA.   +5 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Brief communication: characteristics of primary drug resistance in newly diagnosed HIV-infected individuals in Ganzhou, China. [PDF]

AIDS Res Ther
Huang DD, Liu JJ, Chen YT, Yang RR, Su JZ, Gao Q, Chen X.   +6 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source