Results 81 to 90 of about 1,595 (133)

Internal Circadian Misalignment of the Human Metabolome Links Night Shiftwork to Metabolic Impairment. [PDF]

J Biol Rhythms
Kubicki M, McHill AW, Melanson EL, Reisdorph N, Wright KP, Depner CM.   +5 more
europepmc   +1 more source

Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase.

Nucleosides and Nucleotides, 1996
Abstract The synthesis of 2′-deoxy and 2′,3′-dideoxy derivatives of 1-s-D-ribofuranosyl-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (2) was undertaken in order to find new cytidine deaminase (CDA) inhibitors and potential adjuvants in anticancer chemotherapy.
G. Cristalli, R. Volpini, S. Vittori, CAMAIONI, Emidio, G. Rafaiani, S. Potenza, A. Vita   +6 more
openaire   +3 more sources

Bacterial cytidine deaminases as versatile activators of fluoropyrimidine nucleoside prodrugs

European Journal of Medicinal Chemistry
A platform for modification of 5-fluoropyrimidine nucleosides as potential prodrugs has been developed utilizing bacterial-derived cytidine deaminases (CDAs) for activation. It has been demonstrated that CDA_EH, CDA_F14, and CDA_Lsp effectively convert 5-fluoropyrimidine analogs into 5-fluoro-(2'-deoxy)uridine exhibiting cytotoxic effects.
Ágota Aučynaitė, Arūnas Kazlauskas, Audrius Laurynenas   +2 more
exaly   +4 more sources

Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing

Trends in Biochemical Sciences, 1994
William R. Taylor, Shoumo Bhattacharya, Naveenan Navaratnam   +2 more
exaly   +3 more sources

Nucleoside deaminase and adenosine deaminase activities in regenerating mouse liver

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract The specific activities of nucleoside deaminase (cytidine aminohydrolase, EC 3.5.4.5) and adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) were determined in extracts of mouse liver following 70 % hepatectomy. There was an increase in the levels of these enzymes which preceded the onset of DNA synthesis by many hours. Enzyme levels
I K, Rothman, R, Silber, K M, Klein, F F, Becker   +3 more
openaire   +2 more sources

Adenosine Deaminase in Nucleoside Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mukta Gupta, Vasu Nair
openaire   +1 more source

Deaminases of purines, pyrimidines, nucleosides and nucleotides

1967
The enzymes comprising this group catalyse the hydrolytic cleavage of the amino group in aminopurines and aminopyrimidines. Most of these enzymes possess a high degree of specificity, not only with regard to the particular purine or pyrimidine base, but also depending on whether the substrate is present in the form of the free base, or in combined form
exaly   +4 more sources

Adenosine Deaminase in Nucleoside Synthesis. A Review

Collection of Czechoslovak Chemical Communications, 2006
Adenosine deaminase (ADA) is an enzyme in the purine salvage pathway that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This deamination is an important factor in limiting the usefulness of adenosine analogues in chemotherapy.
Mukta Gupta, Vasu Nair
openaire   +1 more source

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs

Expert Opinion on Drug Metabolism & Toxicology, 2014
Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary for proliferation and progression.
Cindy, Serdjebi, Gérard, Milano, Joseph, Ciccolini   +2 more
openaire   +2 more sources