Results 81 to 90 of about 1,571 (134)
Evolution of two metabolic genes involved in nucleotide and amino acid metabolism in Pseudomonas aeruginosa. [PDF]
PLoS OneWu Y, Shi Y, Liang X.
europepmc +1 more source
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Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase.
Nucleosides and Nucleotides, 1996Abstract The synthesis of 2′-deoxy and 2′,3′-dideoxy derivatives of 1-s-D-ribofuranosyl-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (2) was undertaken in order to find new cytidine deaminase (CDA) inhibitors and potential adjuvants in anticancer chemotherapy.
G. Cristalli +6 more
openaire +3 more sources
Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing
Trends in Biochemical Sciences, 1994William Taylor +2 more
exaly +3 more sources
Bacterial cytidine deaminases as versatile activators of fluoropyrimidine nucleoside prodrugs
European Journal of Medicinal ChemistryA platform for modification of 5-fluoropyrimidine nucleosides as potential prodrugs has been developed utilizing bacterial-derived cytidine deaminases (CDAs) for activation. It has been demonstrated that CDA_EH, CDA_F14, and CDA_Lsp effectively convert 5-fluoropyrimidine analogs into 5-fluoro-(2'-deoxy)uridine exhibiting cytotoxic effects.
Ágota Aučynaitė +2 more
exaly +4 more sources
Nucleoside deaminase and adenosine deaminase activities in regenerating mouse liver
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract The specific activities of nucleoside deaminase (cytidine aminohydrolase, EC 3.5.4.5) and adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) were determined in extracts of mouse liver following 70 % hepatectomy. There was an increase in the levels of these enzymes which preceded the onset of DNA synthesis by many hours. Enzyme levels
I K, Rothman +3 more
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Adenosine Deaminase in Nucleoside Synthesis
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mukta Gupta, Vasu Nair
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Adenosine Deaminase in Nucleoside Synthesis. A Review
Collection of Czechoslovak Chemical Communications, 2006Adenosine deaminase (ADA) is an enzyme in the purine salvage pathway that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This deamination is an important factor in limiting the usefulness of adenosine analogues in chemotherapy.
Mukta Gupta, Vasu Nair
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Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs
Expert Opinion on Drug Metabolism & Toxicology, 2014Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary for proliferation and progression.
Cindy, Serdjebi +2 more
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A new screening method for adenosine deaminase and nucleoside phosphorylase
Journal of Immunological Methods, 1976An improved screening test for both adenosine deaminase and nucleoside phosphorylase is described.
P J, Blake, J F, Greally
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Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout
Clinica Chimica Acta, 19751. Erythrocyte adenosine deaminase (EC 3.5.4.4) and purine nucleoside (inosine) phosphorylase (EC 2.4.1.1) were measured in 33 healthy controls and 43 primary gouty subjects. Adenosine deaminase activity in controls and gouty subjects was 0.373 plus or minus 0.108 and 0.457 plus or minus 0.140 A unit per 5-10-3 ml packed red cells per h, respectively.
T, Nishizawa +3 more
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