Results 101 to 110 of about 1,595 (133)
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Non-nucleoside adenosine deaminase inhibitors: 2000 – 2004
Expert Opinion on Therapeutic Patents, 2005Adenosine deaminase (ADA) is a crucial enzyme in purine metabolism that irreversibly deaminates adenosine to form inosine. ADA is ubiquitous in human tissues and plays a crucial role in immune system development. ADA inhibitors may be useful for the treatment of ischaemic injury, hypertension, lymphomas and leukaemia.
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Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia
1980Significant progress in the classification of leukemia has been achieved by the introduction of methods which make detailled characterisation of cell membrane antigens or receptors possible (1). These methods have proved to be of considerable clinical relevance as tools for precise classification of the underlying leukemic process, thus providing more ...
H, Ludwig +3 more
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Synthesis, 2005
Adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA) are enzymes that catalyze the hydrolytic deamination of various purine nucleosides. In light of recent reports, ADA and AMPDA may be considered as valuable biocatalysts in nucleoside chemistry.
E. Santaniello +2 more
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Adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA) are enzymes that catalyze the hydrolytic deamination of various purine nucleosides. In light of recent reports, ADA and AMPDA may be considered as valuable biocatalysts in nucleoside chemistry.
E. Santaniello +2 more
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Pediatrics International, 1981
Summary We have established the screening methods for PNP and ADA deficiencies and screened 41 immunodeficient patients since 1976. Two of 8 patients with combined immunodeficiency have been found to have ADA deficiency. They were the first and second cases in Japan. The second case with ADA deficiency, born of a second-cousin marriage, was a
Nobuo Sakura +2 more
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Summary We have established the screening methods for PNP and ADA deficiencies and screened 41 immunodeficient patients since 1976. Two of 8 patients with combined immunodeficiency have been found to have ADA deficiency. They were the first and second cases in Japan. The second case with ADA deficiency, born of a second-cousin marriage, was a
Nobuo Sakura +2 more
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Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase
1979Inherited deficiencies of the enzymes adenosine deaminase (ADA) (E.C.3.5.4.4) and purine nucleoside phosphorylase (PNP) (E.C.2.4.2.1) recently have been associated with human immunodeficiency disease1,2. There are two puzzling dilemmas to explain in these conditions.
D. A. Carson, J. Kaye, J. E. Seegmiller
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[71] Cytosine nucleoside deaminase from Escherichia coli
1955Publisher Summary This chapter discusses the determination of cytosine nucleoside deaminase from Escherichia coli (E. coli) . Spectrophotometric methods are used in following the activity of this enzyme, since the deamination of the cytosine compounds is accompanied b y a decrease in absorption of 55 % at 282 mμ.
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Cytidine deaminases catalyze the conversion of N(S,O)4-substituted pyrimidine nucleosides
Science Advances, 2023Justas Vaitekunas +2 more
exaly
Specificity of inhibition of adenosine deaminase by trialcohols derived from nucleosides
Journal of Medicinal Chemistry, 1973R R, Rossi, L M, Lerner
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Inhibition of adenosine deaminase by alcohols derived from adenine nucleosides
Biochemistry, 1972L M, Lerner, R R, Rossi
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