Results 101 to 110 of about 1,562 (132)

Therapy in adenosine deaminase and purine nucleoside phosphorylase deficient patients

Clinical Biochemistry, 1983
The discovery of the causal association of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency with some forms of primary immunodeficiency disease had led to new approaches to therapy, such as enzyme replacement. In ADA deficiency, bone marrow transplantation remains the primary method of choice.
B J, Zegers, J W, Stoop
openaire   +2 more sources

Adenosine deaminase and nucleoside phosphorylase activity in patients with immunodeficiency syndromes

Clinical Immunology and Immunopathology, 1979
Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen, H D, Ochs, C R, Scott, E R, Giblett   +3 more
openaire   +2 more sources

Urinary excretion of purines, purine nucleosides, and pseudouridine in adenosine deaminase deficiency

Biochemical Medicine, 1978
Abstract Previous studies on the urine composition of an adenosine deaminase deficient child have been extended. New analytical procedures have been developed for determination of adenine, deoxyadenosine and adenosine in urine. Of these compounds, deoxyadenosine was the major urinary component.
G C, Mills, R M, Goldblum, K E, Newkirk, F C, Schmalstieg   +3 more
openaire   +2 more sources

Nucleoside Deaminases for Cytidine and Adenosine: Comparison with Deaminases Acting on RNA

2014
This chapter reviews the structure of Escherichia coli cytidine deaminase and implications for evolutionary relationships between members of the cytidine deaminase superfamily. It then summarizes details of the E. coli cytidine deaminase (ECCDA) reaction mechanism, with particular reference to the role of conserved residues and aspects of substrate ...
openaire   +1 more source

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938

European Journal of Pharmacology, 2006
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration.
Masako, Kuno, Nobuo, Seki, Susumu, Tsujimoto, Isao, Nakanishi, Takayoshi, Kinoshita, Katsuya, Nakamura, Tadashi, Terasaka, Nobuya, Nishio, Akihiro, Sato, Takashi, Fujii   +9 more
openaire   +2 more sources

Deaminases of purines, pyrimidines, nucleosides and nucleotides

1967
The enzymes comprising this group catalyse the hydrolytic cleavage of the amino group in aminopurines and aminopyrimidines. Most of these enzymes possess a high degree of specificity, not only with regard to the particular purine or pyrimidine base, but also depending on whether the substrate is present in the form of the free base, or in combined form
openaire   +1 more source

Activity of Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA) Towards 6‐Chloropurine Nucleosides Modified in the Ribose Moiety

European Journal of Organic Chemistry, 2004
AbstractThe enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐O‐isopropylidene derivative, but show no activity towards the 3,4‐O‐isopropylidene‐1‐methylriboside of 6‐chloropurine and adenine. (© Wiley‐VCH Verlag GmbH & Co. KGaA,
P.Ciuffreda, B.Buzzi, L. Alessandrini, E. Santaniello   +3 more
openaire   +1 more source

Synthesis of Modified Purine Nucleosides and Related Compounds Mediated by Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA)

Synthesis, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Enzo Santaniello, Pierangela Ciuffreda, Laura Alessandrini   +2 more
openaire   +2 more sources

Non-nucleoside adenosine deaminase inhibitors: 2000 – 2004

Expert Opinion on Therapeutic Patents, 2005
Adenosine deaminase (ADA) is a crucial enzyme in purine metabolism that irreversibly deaminates adenosine to form inosine. ADA is ubiquitous in human tissues and plays a crucial role in immune system development. ADA inhibitors may be useful for the treatment of ischaemic injury, hypertension, lymphomas and leukaemia.
openaire   +1 more source

Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities during Culturing of Fibrolasts

1980
Fibroblast cultures can be used as a valuable model for the study of inborn errors and as an important diagnostic tool, e.g. amniotic fluid derived fibroblasts in prenatal diagnosis (1–3). In order to develop reliable enzyme assays of fibroblasts the effect of cell culture conditions on enzyme activities should be known.
M P, Uitendaal, F T, Oerlemans, C H, de Bruyn, T L, Oei, P, Hösli   +4 more
openaire   +2 more sources