Results 91 to 100 of about 1,595 (133)
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A new screening method for adenosine deaminase and nucleoside phosphorylase
Journal of Immunological Methods, 1976An improved screening test for both adenosine deaminase and nucleoside phosphorylase is described.
P J, Blake, J F, Greally
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Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout
Clinica Chimica Acta, 19751. Erythrocyte adenosine deaminase (EC 3.5.4.4) and purine nucleoside (inosine) phosphorylase (EC 2.4.1.1) were measured in 33 healthy controls and 43 primary gouty subjects. Adenosine deaminase activity in controls and gouty subjects was 0.373 plus or minus 0.108 and 0.457 plus or minus 0.140 A unit per 5-10-3 ml packed red cells per h, respectively.
T, Nishizawa +3 more
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Therapy in adenosine deaminase and purine nucleoside phosphorylase deficient patients
Clinical Biochemistry, 1983The discovery of the causal association of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency with some forms of primary immunodeficiency disease had led to new approaches to therapy, such as enzyme replacement. In ADA deficiency, bone marrow transplantation remains the primary method of choice.
B J, Zegers, J W, Stoop
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Journal of Medicinal Chemistry, 1979
A series of hexofuranosyladenine nucleosides have been tested as substrates and inhibitors of adenosine deaminase from calf intestinal mucosa. The nucleosides differed from each other in configuration at the various carbon atoms of the hexose and had either a methyl group or hydroxymethyl group at the terminal position.
A J, Grant, L M, Lerner
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A series of hexofuranosyladenine nucleosides have been tested as substrates and inhibitors of adenosine deaminase from calf intestinal mucosa. The nucleosides differed from each other in configuration at the various carbon atoms of the hexose and had either a methyl group or hydroxymethyl group at the terminal position.
A J, Grant, L M, Lerner
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Clinical Immunology and Immunopathology, 1979
Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen +3 more
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Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen +3 more
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Nucleoside Deaminases for Cytidine and Adenosine: Comparison with Deaminases Acting on RNA
2014This chapter reviews the structure of Escherichia coli cytidine deaminase and implications for evolutionary relationships between members of the cytidine deaminase superfamily. It then summarizes details of the E. coli cytidine deaminase (ECCDA) reaction mechanism, with particular reference to the role of conserved residues and aspects of substrate ...
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Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938
European Journal of Pharmacology, 2006Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration.
Masako, Kuno +9 more
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Biochemical Medicine, 1978
Abstract Previous studies on the urine composition of an adenosine deaminase deficient child have been extended. New analytical procedures have been developed for determination of adenine, deoxyadenosine and adenosine in urine. Of these compounds, deoxyadenosine was the major urinary component.
G C, Mills +3 more
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Abstract Previous studies on the urine composition of an adenosine deaminase deficient child have been extended. New analytical procedures have been developed for determination of adenine, deoxyadenosine and adenosine in urine. Of these compounds, deoxyadenosine was the major urinary component.
G C, Mills +3 more
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European Journal of Organic Chemistry, 2004
AbstractThe enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐O‐isopropylidene derivative, but show no activity towards the 3,4‐O‐isopropylidene‐1‐methylriboside of 6‐chloropurine and adenine. (© Wiley‐VCH Verlag GmbH & Co. KGaA,
P.Ciuffreda +3 more
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AbstractThe enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐O‐isopropylidene derivative, but show no activity towards the 3,4‐O‐isopropylidene‐1‐methylriboside of 6‐chloropurine and adenine. (© Wiley‐VCH Verlag GmbH & Co. KGaA,
P.Ciuffreda +3 more
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Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities during Culturing of Fibrolasts
1980Fibroblast cultures can be used as a valuable model for the study of inborn errors and as an important diagnostic tool, e.g. amniotic fluid derived fibroblasts in prenatal diagnosis (1–3). In order to develop reliable enzyme assays of fibroblasts the effect of cell culture conditions on enzyme activities should be known.
M P, Uitendaal +4 more
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