Results 111 to 120 of about 1,562 (132)

Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia

1980
Significant progress in the classification of leukemia has been achieved by the introduction of methods which make detailled characterisation of cell membrane antigens or receptors possible (1). These methods have proved to be of considerable clinical relevance as tools for precise classification of the underlying leukemic process, thus providing more ...
H, Ludwig, H, Winterleitner, R, Kuzmits, M M, Müller   +3 more
openaire   +2 more sources

Screening for Adenosine Deaminase or Purine Nucleoside Phosphorylase Deficiency and a Report of Two Patients with Adenosine Deaminase Deficiency

Pediatrics International, 1981
Summary We have established the screening methods for PNP and ADA deficiencies and screened 41 immunodeficient patients since 1976. Two of 8 patients with combined immunodeficiency have been found to have ADA deficiency. They were the first and second cases in Japan. The second case with ADA deficiency, born of a second-cousin marriage, was a
Nobuo Sakura, Tomofusa Usui, Kazuhiko Ito   +2 more
openaire   +1 more source

Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size

Journal of Medicinal Chemistry, 1981
Five beta-D-ribofuranosyl cyclic urea nucleosides (14-18), ranging in ring size from five to eight membered, were synthesized and evaluated as cytidine deaminase (CDA) inhibitors. The precursor protected nucleosides (9-13) were prepared by a condensation procedure utilizing persilylated ureas with a halo sugar under the specific catalytic activity of a
P S, Liu, V E, Marquez, J S, Driscoll, R W, Fuller, J J, McCormack   +4 more
openaire   +2 more sources

[71] Cytosine nucleoside deaminase from Escherichia coli

1955
Publisher Summary This chapter discusses the determination of cytosine nucleoside deaminase from Escherichia coli (E. coli) . Spectrophotometric methods are used in following the activity of this enzyme, since the deamination of the cytosine compounds is accompanied b y a decrease in absorption of 55 % at 282 mμ.
openaire   +1 more source

Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase

1979
Inherited deficiencies of the enzymes adenosine deaminase (ADA) (E.C.3.5.4.4) and purine nucleoside phosphorylase (PNP) (E.C.2.4.2.1) recently have been associated with human immunodeficiency disease1,2. There are two puzzling dilemmas to explain in these conditions.
D. A. Carson, J. Kaye, J. E. Seegmiller
openaire   +1 more source

Specificity of inhibition of adenosine deaminase by trialcohols derived from nucleosides

Journal of Medicinal Chemistry, 1973
R R, Rossi, L M, Lerner
openaire   +2 more sources

Inhibition of adenosine deaminase by alcohols derived from adenine nucleosides

Biochemistry, 1972
L M, Lerner, R R, Rossi
openaire   +2 more sources

Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases

Cell, 2022
Sung-Ik Cho, Seonghyun Lee, Kayeong Lim   +2 more
exaly  

Nucleoside deaminase activity in viral leukemia.

Cancer research, 1971
Rothman, I K, Malathi, V G, Silber, R
openaire   +1 more source

Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases

Nucleic Acids Research, 2012
Rena A Mizrahi, Peter A Beal, Beal Peter A   +2 more
exaly