Results 131 to 140 of about 2,664 (174)

Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout

Clinica Chimica Acta, 1975
1. Erythrocyte adenosine deaminase (EC 3.5.4.4) and purine nucleoside (inosine) phosphorylase (EC 2.4.1.1) were measured in 33 healthy controls and 43 primary gouty subjects. Adenosine deaminase activity in controls and gouty subjects was 0.373 plus or minus 0.108 and 0.457 plus or minus 0.140 A unit per 5-10-3 ml packed red cells per h, respectively.
T, Nishizawa, Y, Nishida, I, Akaoka, T, Yoshimura   +3 more
openaire   +2 more sources

Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
We searched for non-nucleoside inhibitors of adenosine deaminase by rational structure-based de novo design and succeeded in the discovery of 1-(1-hydroxy-4-phenyl-2-butyl)imidazole-4-carboxamide (FR221647: K(i)=5.9 microM to human ADA) as a novel inhibitor with moderate activity and good pharmacokinetics compared with the known inhibitors pentostatin ...
Tadashi, Terasaka, Isao, Nakanishi, Katsuya, Nakamura, Yoshiteru, Eikyu, Takayoshi, Kinoshita, Nobuya, Nishio, Akihiro, Sato, Masako, Kuno, Nobuo, Seki, Kazuo, Sakane   +9 more
openaire   +3 more sources

Therapy in adenosine deaminase and purine nucleoside phosphorylase deficient patients

Clinical Biochemistry, 1983
The discovery of the causal association of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency with some forms of primary immunodeficiency disease had led to new approaches to therapy, such as enzyme replacement. In ADA deficiency, bone marrow transplantation remains the primary method of choice.
B J, Zegers, J W, Stoop
openaire   +2 more sources

A new screening method for adenosine deaminase and nucleoside phosphorylase

Journal of Immunological Methods, 1976
An improved screening test for both adenosine deaminase and nucleoside phosphorylase is described.
P J, Blake, J F, Greally
openaire   +2 more sources

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938

European Journal of Pharmacology, 2006
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration.
Masako, Kuno, Nobuo, Seki, Susumu, Tsujimoto, Isao, Nakanishi, Takayoshi, Kinoshita, Katsuya, Nakamura, Tadashi, Terasaka, Nobuya, Nishio, Akihiro, Sato, Takashi, Fujii   +9 more
openaire   +2 more sources

Non-nucleoside adenosine deaminase inhibitors: 2000 – 2004

Expert Opinion on Therapeutic Patents, 2005
Adenosine deaminase (ADA) is a crucial enzyme in purine metabolism that irreversibly deaminates adenosine to form inosine. ADA is ubiquitous in human tissues and plays a crucial role in immune system development. ADA inhibitors may be useful for the treatment of ischaemic injury, hypertension, lymphomas and leukaemia.
openaire   +1 more source

Hexofuranosyladenine nucleosides as substrates and inhibitors of calf intestional adenosine deaminase

Journal of Medicinal Chemistry, 1979
A series of hexofuranosyladenine nucleosides have been tested as substrates and inhibitors of adenosine deaminase from calf intestinal mucosa. The nucleosides differed from each other in configuration at the various carbon atoms of the hexose and had either a methyl group or hydroxymethyl group at the terminal position.
A J, Grant, L M, Lerner
openaire   +2 more sources

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs

Expert Opinion on Drug Metabolism & Toxicology, 2014
Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary for proliferation and progression.
Cindy, Serdjebi, Gérard, Milano, Joseph, Ciccolini   +2 more
openaire   +2 more sources

Adenosine deaminase and nucleoside phosphorylase activity in patients with immunodeficiency syndromes

Clinical Immunology and Immunopathology, 1979
Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen, H D, Ochs, C R, Scott, E R, Giblett   +3 more
openaire   +2 more sources

Deaminases of purines, pyrimidines, nucleosides and nucleotides

1967
The enzymes comprising this group catalyse the hydrolytic cleavage of the amino group in aminopurines and aminopyrimidines. Most of these enzymes possess a high degree of specificity, not only with regard to the particular purine or pyrimidine base, but also depending on whether the substrate is present in the form of the free base, or in combined form
openaire   +1 more source