Results 1 to 10 of about 42,264 (252)

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor [PDF]

BMC Biology, 2021
Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. Results We constructed loss-of-function mutants of NDPK-D, lacking either
Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon, Jérôme Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Thérond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bièche, Uwe Schlattner, Mathieu Boissan   +28 more
doaj   +3 more sources

An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase function [PDF]

Journal of Bacteriology
MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any residue. Major MutT proteins hydrolyze 8-oxo-(d)GTP (8-oxo-GTP or 8-oxo-dGTP) to the corresponding 8-oxo-
Elhassan Ali Fathi Emam, Koyel Roy, Devendra Pratap Singh, Deepak K. Saini, Umesh Varshney   +4 more
doaj   +3 more sources

Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype. [PDF]

Parasit Vectors, 2016
BackgroundNucleoside diphosphate kinase b (NDKb) is responsible for nucleoside triphosphates synthesis and it has key role in the purine metabolism in trypanosomatid protozoans.
Moreira DS, Murta SM.
europepmc   +4 more sources

Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2013
Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing.
Florian Georgescauld, Lucile Moynié, Johann Habersetzer, Laura Cervoni, Iulia Mocan, Tudor Borza, Pernile Harris, Alain Dautant, Ioan Lascu   +8 more
doaj   +3 more sources

Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis. [PDF]

BMC Struct Biol, 2015
BackgroundNucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response.
Vieira PS, de Giuseppe PO, Murakami MT, de Oliveira AH.   +3 more
europepmc   +4 more sources

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation. [PDF]

Sci Signal, 2021
The enzyme NDPK-D promotes changes in mitochondrial function that support inflammasome activation. An energetic checkpoint for inflammasomes Intracellular bacterial pathogens elicit inflammatory responses through inflammasomes, which are primed by a TLR ...
Ernst O, Sun J, Lin B, Banoth B, Dorrington MG, Liang J, Schwarz B, Stromberg KA, Katz S, Vayttaden SJ, Bradfield CJ, Slepushkina N, Rice CM, Buehler E, Khillan JS, McVicar DW, Bosio CM, Bryant CE, Sutterwala FS, Martin SE, Lal-Nag M, Fraser IDC.   +21 more
europepmc   +2 more sources

Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. [PDF]

J Bacteriol, 2019
Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, is known for its critical role in homeostasis of cellular nucleotide pools. However, NDK has now emerged as a molecule with pleiotropic effects in DNA repair, protein phosphorylation, gene ...
Kapoor I, Emam EAF, Shaw A, Varshney U.
europepmc   +2 more sources

Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. [PDF]

J Biol Chem, 2019
The fundamental biological function of nucleoside diphosphate kinase (NDK) is to catalyze the reversible exchange of the γ-phosphate between nucleoside triphosphate (NTP) and nucleoside diphosphate (NDP). This kinase also has functions that extend beyond
Wang Y, Wang S, Nie X, Yang K, Xu P, Wang X, Liu M, Yang Y, Chen Z, Wang S.   +9 more
europepmc   +2 more sources

Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA damage responses [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND NME23/NDPKs are well conserved proteins found in all living organisms. In addition to being nucleoside diphosphate kinases (NDPK), they are multifunctional enzymes involved in different processes such as DNA stability, gene regulation and DNA
Chantal Reigada, Melisa Sayé, Fabio Di Girolamo, Edward A Valera-Vera, Claudio A Pereira, Mariana R Miranda   +5 more
doaj   +2 more sources

A phosphohistidine phosphatase promotes starvation survival by dephosphorylating nucleoside diphosphate kinase [PDF]

Cell Reports
Summary: Nucleoside diphosphate kinase (Ndk) is a ubiquitous enzyme that maintains the cellular nucleoside triphosphate (NTP) pool and participates in many other pathways of eukaryotes and prokaryotes.
Akash R. Sinha, Mark Goulian
doaj   +2 more sources