Results 91 to 100 of about 42,303 (291)

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease

Advanced Science, 2023
The nuclear N6‐methyladenosine (m6A) reader YT521‐B homology‐domain‐containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity.
Xuejun Ge, Gang Xue, Yan Ding, Ran Li, Kaining Hu, Tengjiao Xu, Ming Sun, Wang Liao, Bin Zhao, Chuangyu Wen, Jie Du   +10 more
doaj   +1 more source

The cystic fibrosis transmembrane recruiter the alter ego of CFTR as a multi-kinase anchor [PDF]

, 2007
This review focuses on a newly discovered interaction between protein kinases involved in cellular energetics, a process that may be disturbed in cystic fibrosis for unknown reasons.
Anil Mehta, B Amutha, GK Bandyopadhyay, K Barnes, RM Biondi, MH Bosnar, S Braun, RM Crawford, RM Crawford, RM Crawford, S Dabernat, G D'Andrea, D Deitcher, A Dinudom, A Dinudom, BF Dowd, S Dorion, PP Dzeja, PP Dzeja, DM Gordon, I Gimenez, WB Guggino, KR Hallows, DG Hardie, E Janssen, M Kato, P Komwatana, KS Krishnan, YC Long, S Lutz, A Mehta, A Mehta, CE Milla, A Moran, T Moudiou, WW Muhonen, R Muimo, R Muimo, S Puntheeranurak, E Provost, R Rauh, RM Reznick, R Rikhy, EM Schwiebert, VA Selivanov, IS Seong, BL Shapiro, EJ Sims, B Strandvik, KJ Treharne, KJ Treharne, HM Villullas, T Wieland   +52 more
core   +1 more source

Autophosphorylation of nucleoside diphosphate kinase from Myxococcus xanthus [PDF]

Journal of Bacteriology, 1993
The nucleoside diphosphate kinase (NDP kinase) from Myxococcus xanthus has been purified to homogeneity and crystallized (J. Munoz-Dorado, M. Inouye, and S. Inouye, J. Biol. Chem. 265:2702-2706, 1990). In the presence of ATP, the NDP kinase was autophosphorylated.
J, Muñoz-Dorado, N, Almaula, S, Inouye, M, Inouye   +3 more
openaire   +2 more sources

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Substrate Induced Structural and Dynamics Changes in Human Phosphomevalonate Iinase and Implications for Mechanism [PDF]

, 2009
Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans.
Cai, Sheng, Hannongbua, Supa, Herdendorf, Timothy J, Miziorko, Henry M, Olson, Andrew Lawrence, Saparpakom, Patchareenat, Sem, Daniel S., Yao, Huili   +7 more
core   +2 more sources

Nucleoside diphosphate kinase/Nm23 and Epstein–Barr virus [PDF]

Molecular and Cellular Biochemistry, 2009
Nm23-H1 was discovered as the first metastasis suppressor gene about 20 years ago. Since then, extensive work has contributed to understanding its role in various cellular signaling pathways. Its association with a range of human cancers as well as its ability to regulate cell cycle and suppress metastasis has been explored. We have determined that the
Masanao, Murakami, Rajeev, Kaul, Pankaj, Kumar, Erle S, Robertson   +3 more
openaire   +2 more sources

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source