Results 111 to 120 of about 42,303 (291)

Nucleoside Diphosphate Kinase (nm23 Protein) Expression in Retinoblastoma

Ophthalmic Research, 2000
Forty-two enucleated eyes of 42 patients with unilateral retinoblastoma were studied histologically, including histochemically examiantion with anti-nm23 polyclonal antibody which does not recognise cDNA but its product. Primary tumours of >15 mm diameter with less evidence of apoptosis and with the most pleomorphic and anaplastic nuclei were ...
Gunalp, I, Bulay, O, Bardak, Y, Cekic, O, Ayhan, A   +4 more
openaire   +4 more sources

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Targeting NME3 to Restore Mitochondrial Fission‐Fusion Balance Defines a Novel Disease‐Modifying Strategy for Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
NME3 deficiency disrupts mitochondrial fission‐fusion balance, causing neuronal damage via ROS. Pharmacological Drp1 inhibition (Mdivi‐1) or substantia nigra‐specific NME3 overexpression restores mitochondrial equilibrium, prevents dopaminergic neuron loss, and alleviates motor deficits in PD models.
Chen Qiao, Xiang‐Qi Hu, Shen‐Han Xu, Meng‐Fan Yao, Jun‐Peng Liu, Lei Cao   +5 more
wiley   +1 more source

The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans [PDF]

, 2018
Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are fundamental properties of metastatic cells. The first identified metastasis suppressor NM23-H1, which displays nucleoside-diphosphate kinase (NDPK) activity is ...
A Diwakar, A Harłozińska, A Leone, A Leone, A Yokoyama, Alexandra Gráf, AM Rosengard, Anil Mehta, C Baughman, CE Horak, CE Horak, CM Meighan, CR Dearolf, D Ma, DJ Montell, DL Silver, EH Postel, EJ Cram, F Liu, FN Van Leeuwen, G Nallamothu, GP Bell, H Baba, H Miyazaki, H Tagashira, I Andolfo, J Schottenfeld, JA McDonald, JA Woolworth, K Takács-Vellai, KAP Mitchell, Krisztina Takács-Vellai, Krisztián Tárnok, KS Krishnan, L Fancsalszky, Luca Fancsalszky, M Affolter, M Boissan, M Boissan, M Boissan, M Boissan, M Engel, M Fukuda, M Ilijas, M Murakami, M Tokarska-Schlattner, M-C Wong, M-Y Lee, MT Hartsough, N Marino, N Masoudi, P Duchek, PS Steeg, PS Steeg, Q Zhang, R Ferru-Clément, R Lehmann, RF Epand, RK Thakur, RS Parhar, S. Klumpp, SJ Annesley, T Desvignes, T Hsu, T Mochizuki, T Ouatas, U Schlattner, V Dammai, Y Otsuki, Y-T Tee, Z Fan, Zsolt Farkas, Éva Saskői   +72 more
core   +2 more sources

Move beyond free radical theory of aging

iMetaOmics, Volume 3, Issue 1, March 2026.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Nucleoside Diphosphate Kinase from Microorganisms

Journal of Bacteriology and Virology, 2013
Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP or GTP to nucleoside diphosphate.
openaire   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis

Cellular Physiology and Biochemistry, 2013
Background: A growing body of evidence implicates novel roles for nm23-like proteins in the regulation of cellular functions. However, roles of these proteins in islet function and glucose-stimulated insulin secretion (GSIS) remain largely unknown ...
Rajakrishnan Veluthakal, David Kaetzel, Anjaneyulu Kowluru   +2 more
doaj   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Porphyromonas gingivalis‐nucleoside‐diphosphate‐kinase inhibits ATP‐induced reactive‐oxygen‐species via P2X7 receptor/NADPH‐oxidase signalling and contributes to persistence

Cellular Microbiology, 2013
Ligation of P2X7 receptors with a ‘danger signal’, extracellular ATP (eATP), has recently been shown to result in production of intracellular reactive‐oxygen‐species (ROS) in macrophages.
Chul Hee Choi, R. Spooner, Jefferson DeGuzman, Theofilos Koutouzis, D. Ojcius, Ö. Yilmaz   +5 more
semanticscholar   +1 more source