Results 121 to 130 of about 42,303 (291)

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Mitochondrial NME6: A Paradigm Change within the NME/NDP Kinase Protein Family?

Cells
Eukaryotic NMEs/NDP kinases are a family of 10 multifunctional proteins that occur in different cellular compartments and interact with various cellular components (proteins, membranes, and DNA).
Bastien Proust, Maja Herak Bosnar, Helena Ćetković, Malgorzata Tokarska-Schlattner, Uwe Schlattner   +4 more
doaj   +1 more source

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans [PDF]

, 2013
The group I members of the Nm23 (non-metastatic) gene family encode nucleoside diphosphate kinases (NDPKs) that have been implicated in the regulation of cell migration, proliferation and differentiation.
Abdus-Saboor, Andolfo, Biggs, Bilitou, Burdine, Cui, Dammai, Deplagne, Desvignes, Eisenmann, Hartsough, Harłozińska, Heimann, Hippe, Hippe, Hofmann, Hurd, Igawa, Inoue, Kokel, Kolch, Kornfeld, Lee, Mocan, Mochizuki, Müller, Nicholas, Ohmachi, O’Connell, Rochdi, Salerno, Sieburth, Steeg, Steeg, Sundaram, Sundaram, Szewczyk, Takadate, Tso, Wagner, Yochem, Yoder   +41 more
core   +2 more sources

MoRgs3 functions in intracellular reactive oxygen species perception-integrated cAMP signaling to promote appressorium formation in Magnaporthe oryzae

mBio
Regulator of G-protein signaling (RGS) proteins exhibit GTPase-accelerating protein activities to govern G-protein function. In the rice blast fungus Magnaporthe oryzae, there is a family of at least eight RGS and RGS-like proteins (MoRgs1 to MoRgs8 ...
Ruiming Zhang, Xinyu Liu, Jiayun Xu, Chen Chen, Zhaoxuan Tang, Chengtong Wu, Xinyue Li, Lei Su, Muxing Liu, Leiyun Yang, Gang Li, Haifeng Zhang, Ping Wang, Zhengguang Zhang   +13 more
doaj   +1 more source

NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis.

PLoS ONE, 2015
Gastric cancer is one of the most common malignancies and has a high rate of metastasis. We hypothesize that NME2 (Nucleoside Diphosphate Kinase 2), which has previously been considered as an anti-metastatic gene, plays a role in the invasiveness of ...
Yan-fei Liu, Aijun Yang, Wei Liu, Chenyu Wang, Min Wang, Lihan Zhang, Dongcang Wang, Jing-fei Dong, Min Li   +8 more
doaj   +1 more source

Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]

, 2003
Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles, Freeman, Nicola V. E., Newby, Andrew C., Sala-Newby, Graciela B.   +3 more
core   +1 more source

The microtubule-associated nucleoside diphosphate kinase.

Journal of Biological Chemistry, 1984
Microtubule protein prepared by cycles of assembly-disassembly contains a nucleoside diphosphate kinase (NDP kinase) activity. We have isolated the NDP kinase responsible for this activity from twice-polymerized bovine brain microtubule protein by a five-step chromatographic procedure.
J A, Nickerson, W W, Wells
openaire   +2 more sources

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]

, 2008
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W., Bollinger, J. Martin, Jr., Brown, Daniel M., Cameron, Craig E., Edathil, Jocelyn P., Galarraga, Jessica E., Graci, Jason D., Harki, Daniel A., Loakes, David, Peterson, Blake R., Smidansky, Eric D., Too, Kathleen   +11 more
core   +4 more sources

Cloning, Expression, and Purification of Nucleoside Diphosphate Kinase from Acinetobacter baumannii

Enzyme Research, 2013
Acinetobacter baumannii is a multidrug resistant pathogenic bacteria associated with hospital acquired infections. This bacterium possesses a variety of resistance mechanisms which makes it more difficult to control the bacterium with conventional drugs,
J. Sikarwar, S. Kaushik, M. Sinha, P. Kaur, Sujata Sharma, T. Singh   +5 more
semanticscholar   +1 more source