Plant nucleoside diphosphate kinase 1: A housekeeping enzyme with moonlighting activity. [PDF]
Plant Signal Behav, 2018 Nucleoside diphosphate kinase (NDPK) catalyzes the interconversion of nucleoside diphosphates and triphosphates using ATP as phosphate donor. This housekeeping enzyme is present in several subcellular compartments.
Dorion S, Rivoal J.
europepmc +2 more sources
Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis [PDF]
Frontiers in Immunology, 2020 Schistosomiasis, caused by Schistosoma mansoni trematode worm, affects more than 1.5 million people in Brazil. The current treatment consists in the administration of Praziquantel, the only medicine used for treatment for more than 40 years.
Túlio di Orlando Cagnazzo +14 more
doaj +2 more sources
Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H+ leak [PDF]
Pharmaceutical Biology, 2023 Context The toxicity of atractyloside/carboxyatractyloside is generally well recognized and commonly ascribed to the inhibition of mitochondrial ADP/ATP carriers, which are pivotal for oxidative phosphorylation.
Andrzej M. Woyda-Ploszczyca
doaj +2 more sources
A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27. [PDF]
Cell Microbiol, 2018 We have previously shown that a homologue of a conserved nucleoside‐diphosphate‐kinase (Ndk) family of multifunctional enzymes and secreted molecule in Porphyromonas gingivalis can modulate select host molecular pathways including downregulation of ...
Lee J +4 more
europepmc +2 more sources
The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities. [PDF]
Oncotarget, 2018 The NM23/NME gene was identified as a metastasis suppressor. It's re-expression inhibited cancer cell motility and suppressed metastasis, without effecting primary tumor size in multiple model systems.
Khan I, Steeg PS.
europepmc +2 more sources
General and specific promotion of flagellar assembly by a flagellar nucleoside diphosphate kinase. [PDF]
Mol Biol Cell, 2017 Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Zhu X +9 more
europepmc +3 more sources
Nucleoside selectivity of Aspergillus fumigatus nucleoside‐diphosphate kinase
The FEBS Journal, 2020 Aspergillus fumigatus infections are rising at a disconcerting rate in tandem with antifungal resistance rates. Efforts to develop novel antifungals have been hindered by the limited knowledge of fundamental biological and structural mechanisms of A ...
Stephanie Nguyen +3 more
semanticscholar +3 more sources
Evaluation of serum nucleoside diphosphate kinase A for the detection of colorectal cancer. [PDF]
Sci Rep, 2016 We previously described the over-expression of nucleoside diphosphate kinase A (NDKA) in tumours and serum from colorectal cancer (CRC) patients, suggesting its use as biomarker.
Otero-Estévez O +7 more
europepmc +2 more sources
A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure [PDF]
Nanomaterials, 2018 During a heart failure, an increased content and activity of nucleoside diphosphate kinase (NDPK) in the sarcolemmal membrane is responsible for suppressing the formation of the second messenger cyclic adenosine monophosphate (cAMP)—a key component ...
Anushka Ray +4 more
doaj +2 more sources
Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. [PDF]
PLoS Pathogens, 2013 Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are keys to better understand tuberculosis pathogenesis.
Jim Sun +8 more
doaj +2 more sources