Results 231 to 240 of about 42,303 (291)

Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15 cells.

Food and Chemical Toxicology, 2018
The flavonoid myricetin (MYR) is derived from vegetables and fruits. It has been shown to exert anti-cancer effects in various cell lines; however, the exact mechanism underlying these effects is yet to be elucidated. In this study, we evaluated the anti-
J. H. Lee, Y. Choi, See-Hyoung Park, M. Nam   +3 more
semanticscholar   +1 more source

Antiviral Nucleoside Analogs Phosphorylation by Nucleoside Diphosphate Kinase

Mini Reviews in Medicinal Chemistry, 2004
The reaction of NDP kinase was studied in vitro with several antiviral derivatives, using kinetic steady state and presteady state analysis. The enzyme is highly efficient with natural nucleotides but most of the analogs are slow substrates. The catalytic efficiency, also related to the affinity of the analog, is mainly dependent on the presence of a 3'
Gallois-Montbrun, S, Veron, M, Deville-Bonne, D   +2 more
openaire   +2 more sources

Nucleoside diphosphate kinase of Trypanosoma brucei

Gene, 2000
Nucleoside diphosphate kinase (NDPK) is a highly conserved, multifunctional enzyme. Its originally described function is the phosphorylation of nucleoside diphosphates to the corresponding triphosphates, using ATP as the phosphate donor and a high-energy phosphorylated histidine residue as the reaction intermediate.
I, Hunger-Glaser, A, Hemphill, T, Shalaby, M, Hänni, T, Seebeck   +4 more
openaire   +2 more sources

The Human Nm23/Nucleoside Diphosphate Kinases

Journal of Bioenergetics and Biomembranes, 2000
Biochemical experiments over the past 40 years have shown that nucleoside diphosphate (NDP) kinase activity, which catalyzes phosphoryl transfer from a nucleoside triphosphate to a nucleoside diphosphate, is ubiquitously found in organisms from bacteria to human.
M L, Lacombe, L, Milon, A, Munier, J G, Mehus, D O, Lambeth   +4 more
openaire   +2 more sources

Quaternary Structure of Nucleoside Diphosphate Kinases

Journal of Bioenergetics and Biomembranes, 2000
Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but some bacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assembling identical dimers. The hexameric structure is important for protein stability, as demonstrated by studies with natural mutants (the Killer-of-prune mutant of Drosophila NDP ...
L, Lascu, A, Giartosio, S, Ransac, M, Erent   +3 more
openaire   +2 more sources

Arginine kinase shows nucleoside diphosphate kinase-like activity toward deoxythymidine diphosphate

Journal of Bioenergetics and Biomembranes, 2016
Arginine kinase (AK) (ATP: L-arginine phosphotransferase, E.C. 2.7.3.3) catalyzes the reversible transfer of ATP γ-phosphate group to L-arginine to synthetize phospho-arginine as a high-energy storage. Previous studies suggest additional roles for AK in cellular processes.
Alonso A, Lopez-Zavala, Rogerio R, Sotelo-Mundo, Jose M, Hernandez-Flores, Maria E, Lugo-Sanchez, Rocio, Sugich-Miranda, Karina D, Garcia-Orozco   +5 more
openaire   +2 more sources

Three-Dimensional Structure of Nucleoside Diphosphate Kinase

Journal of Bioenergetics and Biomembranes, 2000
Three-dimensional structures are known from X-ray studies of the nucleoside diphosphate (NDP) kinase of many organisms from bacteria to human. All NDP kinases have subunits of about 150 residues with a very similar fold based on the alphabeta sandwich or ferredoxin fold.
J, Janin, C, Dumas, S, Moréra, Y, Xu, P, Meyer, M, Chiadmi, J, Cherfils   +6 more
openaire   +2 more sources

Regulation of Dynamin by Nucleoside Diphosphate Kinase

Journal of Bioenergetics and Biomembranes, 2003
Nucleoside diphosphate (NDP) kinase is required for multiple cellular functions, including cell growth, motility, and differentiation, and its loss is associated with pathologies including tumor metastasis. A recent study has revealed a previously unknown function for NDP kinase as positive regulator of dynamin, a GTPase essential for endocytosis.
Radhakrishnan, Narayanan, Mani, Ramaswami   +1 more
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Nm23/Nucleoside Diphosphate Kinase in Human Cancers

Journal of Bioenergetics and Biomembranes, 2000
Tumor metastasis is the leading cause of death in cancer patients. From a series of tumor cohort studies, low expression of Nm23/NDP kinase has been correlated with poor patient prognosis and survival, lymph node infiltration, and histopathological indicators of high metastatic potential in a number of cancer types, including mammary and ovarian ...
M T, Hartsough, P S, Steeg
openaire   +2 more sources

The Catalytic Mechanism of Nucleoside Diphosphate Kinases

Journal of Bioenergetics and Biomembranes, 2000
Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis.
I, Lascu, P, Gonin
openaire   +2 more sources