Results 81 to 90 of about 42,303 (291)

Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides

Small Structures
Two convergent approaches for synthesizing a new class of nucleoside diphosphate prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides comprise an acyloxybenzyl group in combination with a lipophilic alkyl residue at ...
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson’s disease

ADMET and DMPK, 2020
Parkinson’s disease (PD) is a progressive neurodegenerative disease. Levodopa in combination with amantadine has a demonstrated efficacy in motility impairment. An extensive investigation of some enzymes described to be upregulated or downregulated in PD
Mihaela Ileana Ionescu
doaj   +1 more source

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1 [PDF]

, 2002
Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious.
Du, J., Hannon, G. J.
core   +1 more source

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study [PDF]

, 2012
Objective: Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for standard dosing is controversial.
Chen, Jianmeng, Flexner, Charles, Fuchs, Edward J., Hendrix, Craig W., Liberman, Rosa G., Louissaint, Nicolette A., Skipper, Paul L., Tannenbaum, Steven Robert   +7 more
core   +1 more source

White stripe leaf 12 (WSL12), encoding a nucleoside diphosphate kinase 2 (OsNDPK2), regulates chloroplast development and abiotic stress response in rice (Oryza sativa L.)

Molecular breeding, 2016
Chloroplast is a crucial organelle for plant photosynthesis and maintaining normal life activities in higher plants. Although some genes related to chloroplast development and pigment synthesis have been identified or cloned in rice, little is known ...
Weijun Ye, Shikai Hu, Liwen Wu, Chang-wei Ge, Yongtao Cui, Ping Chen, Xiaoqi Wang, Jie Xu, Deyong Ren, Guojun Dong, Q. Qian, Longbiao Guo   +11 more
semanticscholar   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling

Life Science Alliance
Researchers discover that NME7, a lesser studied protein, is required for cilium assembly and Hedgehog signaling, impacting ciliary microtubule stability. This study advances our understanding of primary cilium assembly and functions.
Menghui Ji, Wenjuan Cui, Qian Feng, Jingjin Qi, Xinmin Wang, Hong Zhu, Wenqing Zhang, Wenxiang Fu   +7 more
doaj   +1 more source

Role of Graphene Oxide in Inhibiting the Interactions between Nucleoside Diphosphate Kinases -B and -C

Micro, 2022
Nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane is crucial for the synthesis of cyclic adenosine monophosphate (cAMP) to maintain the calcium ion balance.
Andrey Zaznaev, Isaac Macwan
doaj   +1 more source