Results 71 to 80 of about 115,586 (202)

Disruption of the GDP-mannose synthesis pathway in Streptomyces coelicolor results in antibiotic hyper-susceptible phenotypes [PDF]

, 2018
Actinomycete bacteria use polyprenol phosphate mannose as a lipid linked sugar donor for extra-cytoplasmic glycosyl transferases that transfer mannose to cell envelope polymers, including glycoproteins and glycolipids.
Green, Katri Anttonen, Kieser, Margaret C. M. Smith, Nicholas Read, Robert Howlett   +5 more
core   +1 more source

A Comprehensive Review of Probiotics in Alleviating Hyperuricemia: Mechanisms, Strain Engineering, and Food Applications

Food Bioengineering, Volume 4, Issue 4, Page 546-563, December 2025.
Screening and modification of probiotics that can efficiently reduce uric acid provide a new strategy for food‐grade hyperuricemia intervention. ABSTRACT Hyperuricemia has become one of the most prevalent global epidemics, significantly impacting both the economy and the health of individuals.
Le Wang, Qi Wu, Mengjia Zhang, Zifu Ni, Pengshuai Zhang, Siyuan Bai, Yibin Wang, Zhongke Sun   +7 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9 [PDF]

, 2011
Background Streptococcus thermophilus represents the only species among the streptococci that has “Generally Regarded As Safe” status and that plays an economically important role in the fermentation of yogurt and cheeses.
Yong Goh, Caitlin Goin, Sarah O’Flaherty, Eric Altermann, Robert Hutkins   +4 more
core   +1 more source

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

In silico antimalarial bioprospecting of neem (Azadirachta indica) quinine-derivative alkaloids

Universitas Scientiarum
Malaria, driven by the protozoan Plasmodium spp. and transmitted by Anopheles mosquitoes, remains a significant global health threat. With the emergence of chloroquine-resistant malaria, alternative treatments derived from natural compounds are pressing.
Alfin Hidayat, Mamat Sugianto, Ali Budhi Kusuma, Lili Suharli, Adhityo Wicaksono   +4 more
doaj   +1 more source

The invertebrate Caenorhabditis elegans biosynthesizes ascorbate. [PDF]

, 2015
l-Ascorbate, commonly known as vitamin C, serves as an antioxidant and cofactor essential for many biological processes. Distinct ascorbate biosynthetic pathways have been established for animals and plants, but little is known about the presence or ...
Adler, Lital N, Budenholzer, Lauren M, Clarke, Steven G, Patananan, Alexander N, Pedraza, Maria E, Torres, Eric R   +5 more
core   +2 more sources

Regional Differences in Soybean Protein and Amino Acid Profiles: A Genetic Exploration Using a Novel GWAS Panel

Legume Science, Volume 7, Issue 4, December 2025.
ABSTRACT Regional differences in soybean seed protein and amino acid content in Canada present significant challenges for crop improvement and the market value of high‐protein livestock feed. This study employed genome‐wide association studies (GWAS) using a novel panel of 206 cultivars to investigate the genetic basis of regional variations.
Siwar Haidar, Simon Lackey, Aga Pajak, Mohamad S. Elian, Vi Nguyen, Jakob Bruggink, Loretta Ross, Fuyou Fu, Jonathan Durkin, Milad Eskandari, Ashkan Golshani, Zenglu Li, Lone Buchwaldt, Yuhai Cui, Anfu Hou, Yong‐Bi Fu, Krzysztof Szczyglowski, Elroy Cober, Frédéric Marsolais, Bahram Samanfar   +19 more
wiley   +1 more source

Pentosyl transfer mechanisms of the mammalian nucleoside phosphorylases.

Journal of Biological Chemistry, 1968
Phosphate dependence obeying Michaelis-Menten type kinetics was found to be a common feature of pentosyl transfer catalyzed by guinea pig uridine phosphorylase and rabbit thymidine phosphorylase.
T. Krenitsky
semanticscholar   +1 more source

Nucleosides are overlooked fuels in central carbon metabolism. [PDF]

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a ...
Blanco-Fernandez, J., Jourdain, A.A., Strefeler, A.   +2 more
core   +1 more source