Results 61 to 70 of about 38,543 (124)
The enzymatic synthesis of nucleoside analogues [PDF]
Ribavirin, 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum antiviral agent active against both DNA and RNA viruses. A range of 1,2,3-triazole, 1,2,4-triazole and benzotriazole analogues of ribavirin was synthesised using a crude ...
O'Connell, Grace Josephine
core
Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases
, 2016 N-Ribosyl phosphorylases and hydrolases catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon from the fixed purine to phosphate and water nucleophiles, respectively.
Richard H. Furneaux (2236435) +5 more
core +1 more source
The distribution and diversity of nucleoside N-deoxyribosyltransferase among lactic acid bacteria [PDF]
Nucleoside N-deoxyribosyltransferases are capable of synthesising stereoand regioselectively a variety of 2'-deoxy- and 2', 3'-dideoxyribonucleosides.
Chawdhri, Rizwana F.
core
The Preparation of Nucleoside-Functionalized Silicone and Oligonucleotide-Silicone Copolymers [PDF]
, 2004 Attempts to prepare silicone oligonucleotide copolymers are complicated by the large difference in hydrophobicity in the two materials. Two approaches were followed to overcome this challenge.
Guo, Kui
core
Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases
, 2011 N-Ribosyl phosphorylases and hydrolases catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon from the fixed purine to phosphate and water nucleophiles, respectively.
Greatrex, Ben +5 more
core +1 more source
Nucleoside phosphorylases and deoxyribonucleoside kinases: the green side of nucleic acid chemistry
, 2016 Biocatalysis has become nowadays an important tool in synthetic organic chemistry. Biotransformations are chemo-, regio-, and stereoselective, occur under mild reaction conditions and are characterized by a reduced use of toxic reagents/solvents.
CATTANEO, GIULIA +9 more
core
, 2009 5'-Deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus (SsMTAPII) and purine nucleoside phosphorylase from Pyrococcus furiosus (PfPNP) are hyperthermophilic purine nucleoside phosphorylases stabilized by intrasubunit disulfide ...
PORCELLI, Marina +3 more
core +1 more source
Pentose phosphates in nucleoside interconversion and catabolism
, 2006 Ribose phosphates are either synthesized through the oxidative branch of the pentose phosphate pathway, or are supplied by nucleoside phosphorylases.
Francesco Sgarrella +9 more
core +2 more sources
The enzymatic and chemical synthesis of nucleoside analogues using N-deoxyribosyltransferase from Lactobacillus leichmannii [PDF]
N-deoxyribosyltransferase catalyses the transfer of 2-deoxy-I 2.3, -dideoxyand 2,5-dideoxyribose sugars between purine and pyrimidine bases. In this work, a crude extract of N-deoxyribosyltransferase from Lactobacillus leichmannii was used in the ...
Hicks, Nicola
core
, 2013 In recent years, glycosiltransferases have arisen as standard biocatalysts for the enzymatic synthesis of a wide variety of natural and non-natural nucleosides.
Arroyo Sánchez, Miguel +3 more
core +1 more source