Results 61 to 70 of about 112 (103)
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Mutations in purine nucleoside phosphorylase deficiency
Human Mutation, 1997Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A174P and G190V, a single codon deletion, delta I129, and a ...
M L, Markert +8 more
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Stroke in purine nucleoside phosphorylase deficiency
Pediatric Neurology, 1995The first documented case of cerebrovascular disease occurring in a 13-year-old girl with purine nucleoside phosphorylase deficiency is reported. This patient, the oldest known survivor with purine nucleoside phosphorylase deficiency, had previously experienced multiple sequential neurologic problems.
D A, Tam, R T, Leshner
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Inhibition of Intestinal Pyrimidine Nucleoside Phosphorylases
Pharmaceutical Research, 1987The activity of 5'-deoxy-5-fluorouridine (dFUR) depends on its activation to 5-fluorouracil (FU) by pyrimidine nucleoside phosphorylases. These enzymes are found in tumors and normal tissues, with the highest activity in the small intestines. The present study examined the inhibition of dFUR phosphorolysis in intestinal tissues.
M G, Wientjes, J L, Au
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Purine nucleoside synthesis: an efficient method employing nucleoside phosphorylases
Biochemistry, 1981An improved method for the enzymatic synthesis of purine nucleosides is described. Pyrimidine nucleosides were used as pentosyl donors and two phosphorylases were used as catalysts. One of the enzymes, either uridine phosphorylase (Urd Pase) or thymidine phosphorylase (dThd Pase), catalyzed the phosphorolysis of the pentosyl donor.
T A, Krenitsky +2 more
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Inhibition of human purine nucleoside phosphorylase by acyclic nucleosides and nucleotides
Biochemical Pharmacology, 1987In an effort to develop more potent inhibitors of human purine nucleoside phosphorylase (PNP) as immunosuppressive and cancer chemotherapeutic agents, the affinity of the erythrocytic enzyme for 30 acyclic nucleosides, nucleotides and related compounds was determined.
J M, Stein +8 more
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Prenatal exclusion of purine nucleoside phosphorylase deficiency
European Journal of Pediatrics, 1986We report on the prenatal exclusion of purine nucleoside phosphorylase (PNP) deficiency in a fetus whose parents were known to be heterozygotes for the enzyme defect. Prenatal investigation was performed in the 16th week of gestation on amniotic fluid and cultured amnion cells using sensitive techniques.
E. Carapella De Luca +6 more
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LINGCOD MUSCLE PURINE NUCLEOSIDE PHOSPHORYLASE
Canadian Journal of Biochemistry and Physiology, 1958A purine nucleoside phosphorylase enzyme preparation, which catalyzed the general reaction ribose (deoxyribose) [Formula: see text] nucleoside (deoxynucleoside)+orthophosphate, was isolated from muscles of the lingcod (Ophiodon elongatus). The reaction was found to be about 85% in favor of nucleoside synthesis with 10 μM./ml.
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16 Purine Nucleoside Phosphorylase
1972Publisher Summary This chapter focuses on purine nucleoside phosphorylases (PNPases), which are widely distributed in nature and have been identified and studied in a number of tissues in mammals, chickens, fish, yeast, and in several species of bacteria. In the erythrocytes of dogs, the activity of PNPase is remarkably low when compared with the red
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Enzymatic Production of Antiviral Nucleosides by the Application of Nucleoside Phosphorylase
Annals of the New York Academy of Sciences, 1990K, Yokozeki, H, Shirae, K, Kubota
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