Results 71 to 80 of about 38,543 (124)

The Crystal Structure of Streptococcus pyogenes Uridine Phosphorylase Reveals a Distinct Subfamily of Nucleoside Phosphorylases

, 2016
Uridine phosphorylase (UP), a key enzyme in the pyrimidine salvage pathway, catalyzes the reversible phosphorolysis of uridine or 2′-deoxyuridine to uracil and ribose 1-phosphate or 2′-deoxyribose 1-phosphate.
Steven E. Ealick (43371), M. Terreni (2179238), Jure Piškur (2179240), William B. Parker (2179232), Timothy H. Tran (1371921), S. Christoffersen (2179242), Paula W. Allan (2179236), I. Serra (2179234)   +7 more
core   +1 more source

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

, 2006
(1R)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-L-ribitol [(+)-5] and (3S,4S)-1-[(9-deazahypoxanthin-9-yl)methyl]-4-(hydroxymethyl)pyrrolidin-3-ol [(-)-6] are the L-enantiomers of immucillin-H (D-ImmH) and DADMe-immucillin-H (D-DADMe-ImmH ...
Schramm, VL, Lenz, DH, Evans, GB, Mee, SP, Tyler, PC, Johnson, SW, Taylor Ringia, EA, Fleet, GW, Clinch, K, Furneaux, RH, Rands, PR   +10 more
core   +1 more source

Microbial nucleoside phosphorylases as efficient biocatalysts for the synthesis of antiviral and antitumoral nucleosides

, 2010
Modified nucleosides, such as 5-fluoro-2'-deoxyuridine (Floxuridine),2',3'-dideoxyinosine (Didanosine), arabinosyladenine (Vidarabine), arabinosyl-2-fluoroadenine (Fludarabine), are important antiviral and antitumor agents.
Amati G., UBIALI, DANIELA, TERRENI, MARCO, Daly Simona, Daly S., SERRA, IMMACOLATA, AMATI, GIUSEPPE, ALBERTINI, ALESSANDRA   +7 more
core   +1 more source

Nucleoside phosphorylases and deoxyribonucleoside kinases: the green side of nucleis acid chemistry

, 2016
Biocatalysis has become nowadays an important tool in synthetic organic chemistry. Biotransformations are chemo-, regio-, and stereoselective, occur under mild reaction conditions and are characterized by a reduced use of toxic reagents/solvents.
G. Massolini, G. Speranza, T. Bavaro, M. Rabuffetti, I. Serra, G. Cattaneo, D. Ubiali, A. M. Albertini, M. Terreni, E. Calleri   +9 more
core  

Thermus thermophilus nucleoside phosphorylases active in the synthesis of nucleoside analogues. [PDF]

Appl Environ Microbiol, 2012
Almendros M, Berenguer J, Sinisterra JV.
europepmc   +1 more source

Thermodynamics of binding to purine nucleoside phosphorylases

, 2009
Purine nucleoside phosphorylases (PNPs) catalyze the reversible interconversion of (deoxy)nucleosides to free purine base and (deoxy)ribose 1-phosphate.
Edwards, Achelle A.
core  

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases. [PDF]

BMC Struct Biol, 2009
Chaikuad A, Brady RL.
europepmc   +1 more source

Exploring Novel Indazole and Pyrazole Nucleoside Analogues: Enzymatic Synthesis, Characterization, and Biological Evaluation. [PDF]

Int J Mol Sci
Mironov AF, Eletskaya BZ, Antonov KV, Paramonov AS, Esipov RS, Konstantinova ID, Andreevskaya SN, Smirnova TG, Karpenko IL, Sokhraneva VA, Zhivotova IS, Kochetkov SN, Khandazhinskaya AL, Matyugina ES.   +13 more
europepmc   +1 more source

Transition state analogue discrimination by related purine nucleoside phosphorylases. [PDF]

J Am Chem Soc, 2006
Taylor Ringia EA, Tyler PC, Evans GB, Furneaux RH, Murkin AS, Schramm VL.   +5 more
europepmc   +1 more source

Production of Modified Nucleosides in a Continuous Enzyme Membrane Reactor. [PDF]

Int J Mol Sci, 2023
Thiele I, Yehia H, Krausch N, Birkholz M, Cruz Bournazou MN, Sitanggang AB, Kraume M, Neubauer P, Kurreck A.   +8 more
europepmc   +1 more source