Results 51 to 60 of about 38,543 (124)
Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases
The growing demand for 4′-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies.
Gert Bange (811040) +11 more
core +1 more source
Activity assay of Purine Nucleoside Phosphorylases by LC-MS/MS
, 2015 In the search for new therapeutics, fast and automated screening tools of chemical libraries are required for hit selection. Nucleoside phosphorylases (NPs, E.C. 2.4.2) are among the key enzymes in nucleotide salvage/recycling pathway. NPs catalyze the
G. Massolini +7 more
core +2 more sources
In silico antimalarial bioprospecting of neem (Azadirachta indica) quinine-derivative alkaloids
Universitas ScientiarumMalaria, driven by the protozoan Plasmodium spp. and transmitted by Anopheles mosquitoes, remains a significant global health threat. With the emergence of chloroquine-resistant malaria, alternative treatments derived from natural compounds are pressing.
Alfin Hidayat +4 more
doaj +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Structure of E. coli 5′-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases [PDF]
, 2001 Background: 5′-methylthioadenosine/S-adenosyl-homocysteine (MTA/AdoHcy) nucleosidase catalyzes the irreversible cleavage of 5′-methylthioadenosine and S-adenosylhomocysteine to adenine and the corresponding thioribose, 5′-methylthioribose and S ...
Riscoe, Michael K. +7 more
core +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, Volume 117, Issue 8, Page 2085-2097, August 2026.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
, 1978 Udgivelsesdato: 1978 AugTwo purine nucleoside phosphorylases (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) were purified from vegetative Bacillus subtilis cells.
Jensen, Kaj Frank
core +1 more source
, 2012 Nucleoside phosphorylases (NPs; E.C. 2.4.2) catalyze the reversible cleavage of the glycosidic bond of (deoxy) ribonucleosides in the presence of inorganic orthophosphate to generate the nucleobase and a-D-(deoxy)ribose-1-phosphate.
Serra C. D. +6 more
core
Do non-nucleoside reverse transcriptase inhibitors contribute to lipodystrophy? [PDF]
, 2005 Lipodystrophy complications, including lipoatrophy (pathological fat loss) and metabolic complications, have emerged as important long-term toxicities associated with antiretroviral therapy in the current era. The wealth of data that has accumulated over
Nolan, D.
core
Isolation and evolution of novel nucleoside phosphorylases [PDF]
, 2010 Approximately 33.4 million people are living with HIV/AIDS. Of those, 97% live in low and middle income countries, with 22.4 million in sub-Saharan Africa.
Visser, Daniel Finsch
core +1 more source