Results 31 to 40 of about 112 (103)
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Ribonucleotide reductases (RNRs) are valuable biocatalysts for the biosynthesis of non‐natural deoxyribonucleotide, relevant in fields like medical science and synthetic biology. In this study, we explore the substrate spectrum of two thermostable RNRs and discuss their implications for nucleotide metabolism and biocatalytical applications ...
Lobna Eltoukhy, Christoph Loderer
wiley +1 more source
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.Researcher highlight: Extending beyond the recently reported compound heterozygous case, we report the same TYMP c.131G>C variant in a homozygous configuration, delivering key genetic evidence for its standalone pathogenicity in MNGIE. ABSTRACT Background Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder ...
Ling Li +6 more
wiley +1 more source
Synthetic and Systems Biotechnology2′-Deoxy-2′-fluoroadenosine (2′-F-dA) is a nucleoside analogue used as a key building block for oligonucleotide drugs. It can be biosynthesized from a low-cost 2′-deoxy-2′-fluorouridine via one-pot transglycosylation catalyzed by a thymidine ...
Dandan Feng +6 more
doaj +1 more source
Boron‐10 carriers and their applications in boron neutron capture therapy
Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang +7 more
wiley +1 more source
Structural insights into urocanate reductase using room‐temperature X‐ray crystallography
Acta Crystallographica Section D, Volume 82, Issue 6, Page 603-614, June 2026.The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal +4 more
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 6, June 2026.Proteomics reveal Chaetoceros simplex‐evolved populations adopt a conservative, resource‐recycling strategy when exposed to above‐optimal temperatures. This involves downregulating biosynthesis, which helps the organism withstand heat stress. However, this strategy may limit their ability to adapt to high temperatures in environments with low nitrate ...
María Aranguren‐Gassis +6 more
wiley +1 more source
Gene Expression and Structural Differences Underpinning Black and White Colouration in Spiders
Molecular Ecology, Volume 35, Issue 12, June 2026.ABSTRACT The presence of multiple color variants within a single population, known as color polymorphism, is a striking example of intraspecific phenotypic variation and a model for studying evolutionary processes. These processes depend on the underlying mechanisms such as the genes and pigments involved; but we currently lack such information for non‐
Fabian C. Salgado‐Roa +3 more
wiley +1 more source
Purine Nucleoside Phosphorylase Deficiency [PDF]
Arthritis & Rheumatism, 1979 AbstractThe biochemical features of two families with purine nucleoside phosphorylase deficiency are compared. Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and nucleoside concentrations in plasma and urine reflect the ...
Robert L. Wortmann +7 more
openaire +1 more source