Results 21 to 30 of about 38,543 (124)

Diversification of 4ʹ-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]

, 2021
The growing demand for 4\u27-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of
Anke, Kurreck, Sarah, Westarp, Peter, Neubauer, Sebastian, Kemper, Felix, Kaspar, Daniel, Werz, Christoph, Köllmann, Patrick, Pausch, Anna P., Lehmann, Margarita, Seeger, Gert, Bange, Anett, Schallmey   +11 more
core   +2 more sources

Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives [PDF]

, 2022
Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable synthetic tool. However, despite the recent advances in nucleoside phosphorylase-catalyzed nucleoside synthesis, the widespread application of these enzymes in industrial ...
Anke, Kurreck, Sarah, Westarp, Peter, Neubauer, Felix, Kaspar   +3 more
core   +1 more source

SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES [PDF]

Biotechnologia Acta, 2013
Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the ...
A. Mikhailopulo, A. I. Miroshnikov
doaj   +1 more source

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations

Molecules, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Heba Yehia, Sarah Westarp, Viola Röhrs, Felix Kaspar, Robert T. Giessmann, Hendrik F.T. Klare, Katharina Paulick, Peter Neubauer, Jens Kurreck, Anke Wagner   +9 more
doaj   +1 more source

Nucleoside Phosphorylases [PDF]

, 2006
Nucleoside phosphorylases (NPs) are transferases that catalyse the reversible cleavage of the glycosidic bond of ribo- or deoxyribo nucleosides, in the presence of inorganic phosphate, to generate the base and ribose- or deoxyribose- 1-phosphate.
Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra   +1 more
core   +1 more source

Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. [PDF]

PLoS ONE, 2014
Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts.
Wenjie Ye, Debamita Paul, Lina Gao, Jolita Seckute, Ramiah Sangaiah, Karupiah Jayaraj, Zhenfa Zhang, P Alexandre Kaminski, Steven E Ealick, Avram Gold, Louise M Ball   +10 more
doaj   +1 more source

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source

Developing a Collection of Immobilized Nucleoside Phosphorylases for the Preparation of Nucleoside Analogues: Enzymatic Synthesis of Arabinosyladenine and 2,3-Dideoxyinosine [PDF]

, 2013
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides.
Serra, Immacolata, Christoffersen, Stig,, Piškur, J., Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra, Christoffersen, Stig, Lewkowicz, Elizabeth S., Albertini, Alessandra M., Ubiali, Daniela, Piskur, Jure, Iribarren, Adolfo M., Lewkowicz, E. S., Christoffersen, S., Terreni, Marco, Iribarren, A. M., ALBERTINI, ALESSANDRA, Lund University.   +16 more
core   +1 more source

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007

Molecules, 2019
Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been reported, the development of highly efficient enzymes for industrial applications is still in high ...
Gaofei Liu, Tiantong Cheng, Jianlin Chu, Sui Li, Bingfang He   +4 more
doaj   +1 more source

Immobilized Enzyme Reactors Based on Nucleoside Phosphorylases (NPs) and Nucleoside 2′-Deoxyribosyltransferases (NDTs) for the In-Flow Synthesis of Nucleoside Analogues

Proceedings, 2019
Enzymes are increasingly used as biocatalysts for the production of Active Pharmaceutical [...]
Marco Terreni, Francesca Rinaldi, Caterina Temporini, Enrica Calleri, Gabriella Massolini, Daniela Ubiali   +5 more
doaj   +1 more source