Quantitative Biology, Volume 13, Issue 4, December 2025.Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley +1 more source
Global transcriptome response in during growth on ribose [PDF]
, 2011 Background Lactobacillus sakei is valuable in the fermentation of meat products and exhibits properties that allow for better preservation of meat and fish. On these substrates, glucose and ribose are the main carbon sources available for growth. We used
Naterstad Kristine +3 more
core +2 more sources
Comparative Analysis of Enzymatic Transglycosylation Using E. coli Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides [PDF]
Int J Mol Sci, 2022 Drenichev MS +7 more
europepmc +1 more source
Synthesis of Ribavirin, Tecadenoson, and Cladribine by enzymatic transglycosylation [PDF]
, 2019 Despite the impressive progress in nucleoside chemistry to date, the synthesis of nucleoside analogues is still a challenge. Chemoenzymatic synthesis has been proven to overcome most of the constraints of conventional nucleoside chemistry.
Bavaro T. +7 more
core +1 more source
Aeromonas hydrophila strains as biocatalysts for transglycosylation [PDF]
, 2010 Microbial transglycosylation is useful as a green alternative in the preparation of purine nucleosides and analogues, especially for those that display pharmacological activities.
Iribarren, Adolfo Marcelo +3 more
core +1 more source
Isolation of Nucleoside Metabolizing Enzymes from Alaska Pea Seeds (Pisum sativum L. cultivar Alaska) [PDF]
, 2013 The activities of number of metabolizing enzymes were determined from dry Alaska Pea Seeds (Pisum sativum L. cultivar Alaska). Then tested for presence of three groups of enzymes; nucleosidase, deaminases and phosphorylases. The highest activity of the
Altawil, Zahrah Mohammad
core +1 more source
Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]
, 2004 The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T. +5 more
core +1 more source
SURVEY OF NUCLEOSIDE DEGRADING ENZYME ACTIVITIES IN SOYBEAN, CORN AND YELLOW LUPIN [PDF]
, 2014 Efficient pyrimidine and purine nucleotide metabolism is essential for healthy growth and development of all organisms. Significant energy cost reduction and a mutation bypass mechanism is afforded via the recycling pathways of nucleotide metabolism in ...
Ustynov, Sergiy
core +1 more source
Oligomeric Symmetry of Purine Nucleoside Phosphorylases
SymmetryMany enzymes are composed of several identical subunits, which are arranged in a regular fashion and usually comply with some definite symmetry. This symmetry may be approximate or exact and may or may not coincide with the symmetry of crystallographic packing.
Boris Gomaz, Zoran Štefanić
openaire +2 more sources