Results 71 to 80 of about 49,657 (223)

HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors

Virology Journal
The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe ...
Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell   +4 more
doaj   +1 more source

Abacavir: it’s use and hypersensitivity

Southern African Journal of HIV Medicine, 2009
Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first and second line therapy as well as a substitute for Stavudine and Zidovudine for toxicity. Although safe and well tolerated, a life threatening hypersensitivity reaction can occur.
Helena Rabie, Kristin Lorenc Henning, Pierre Schoeman, Nico de Villiers, G HJ Pretorius, Mark F Cotton   +5 more
doaj   +1 more source

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy [PDF]

, 2012
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and
Anta, Lourdes, Betancor, Gilberto, Blanco, José L., Garriga, César, Martínez Picado, Francisco Javier, Martínez, Miguel A., Mendoza, Carmen de, Menéndez-Arias, Luis, Nevot Banús, Maria, Puertas, Maria C., Pérez Elías, M. Jesús, Spanish AIDS Research Network (ResRIS)   +11 more
core   +4 more sources

Virological outcomes with Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in people previously treated with darunavir‐based antiretroviral therapy

HIV Medicine, EarlyView.
Abstract Background Darunavir‐based antiretroviral therapy (ART) is commonly used in people with HIV who experience adherence challenges and/or have complex resistance patterns. Changes in ART commissioning have led to an increased use of Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in these populations despite limited real‐world outcome ...
Rhianna Sheridan, Yasmin Osei‐Kuffour Ekert, Lucy Campbell, Mark Zuckerman, Sally Hawkins, Kate Childs, Frank A. Post   +6 more
wiley   +1 more source

Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir

HIV/AIDS: Research and Palliative Care, 2013
Mark A WainbergMcGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, CanadaAbstract: A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non ...
Wainberg MA
doaj  

The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance

Viruses, 2014
Mutations in HIV-1 reverse transcriptase (RT) that confer nucleoside analog RT inhibitor resistance have highlighted the functional importance of several active site residues (M184, Q151 and K65) in RT catalytic function. Of these, K65 residue is notable
Scott J. Garforth, Chisanga Lwatula, Vinayaka R. Prasad   +2 more
doaj   +1 more source

Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation

Viruses, 2020
With the current widespread use of dolutegravir in low-income countries, the understanding of the impact of nucleoside reverse transcriptase inhibitor (NRTI-) associated mutations on the efficacy of dolutegravir-containing antiretroviral therapy (ART) is
Dominique L. Braun, Thomas Scheier, Ulrich Ledermann, Markus Flepp, Karin J. Metzner, Jürg Böni, Huldrych F. Günthard   +6 more
doaj   +1 more source

Interactions of tenofovir, lamivudine, abacavir and didanosine in primary human cells [PDF]

, 2011
Certain triple nucleoside/tide reverse transcriptase inhibitor (NRTI) regimens containing tenofovir (TDF) have been associated with rapid early treatment failure. The mechanism is unknown, but may be at the level of drug transport.
Balimane, Bousquet, Brenner, Chandler, Cihlar, de Souza, Gallant, Gibbs, Gibbs, Giri, Hawkins, Imaoka, Janneh, Janneh, Janneh, Janneh, Kewn, Kewn, Khanlou, Maitland, Mallants, Minderman, Minuesa, Omar Janneh, Pan, Podzamczer, Robbins, Saye Khoo, Shaik, Shiraki, Storch, Tong, Turriziani, van Gelder, Wang, Wang, Waters, Weiss   +37 more
core   +2 more sources

Prevalence of Sleep Apnea and Sleepiness in Adults With and Without HIV in Mwanza, Tanzania: Baseline Results From an Ongoing Cohort Study

Journal of Sleep Research, EarlyView.
ABSTRACT We conducted a cross‐sectional analysis of the baseline survey of participants aged > 30 years enrolled in the Mwanza HIV&CVD Cohort in Tanzania. Our primary objective was to examine the association between HIV status and sleep apnea (SA).
Godfrey A. Kisigo, Benson Issarow, Salama Fadhil, Grace Ruselu, Ponsiano Fabian, Ayubu Garbindi, Robert N. Peck, Kathy Baisley, Saidi Kapiga, Ana C. Krieger   +9 more
wiley   +1 more source

A study on individualized regimen for north Indians living with human immunodeficiency virus-1 subtype C: A public health approach [PDF]

Journal of Krishna Institute of Medical Sciences University, 2023
Background: The study analyses several first line and second line drugs, CD4 counts and viral load in patients experiencing treatment failure over a period of 1 to 6 years of first line Antiretroviral Therapy (ART).
Ashwini Yadav, Srikanth Prasad Tripathy, Tej Pal Singh, Srikanta Jena, Shripad A Patil, Keshar Kunja Mohanty   +5 more
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