Results 281 to 290 of about 197,362 (384)

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans. [PDF]

PLoS Genet
Guan Y, Yu Y, Gao SM, Ding L, Zhao Q, Wang MC.   +5 more
europepmc   +1 more source

Studies on Chemotherapeutic Agents.I. A Synthesis of Pyrimidine Nucleosides of D-glucuronic Acid and Its Derivatives

, 1966
T. Kishikawa, Tsuyoshi Yamazaki, Hidetaka Yuki   +2 more
openalex   +2 more sources

Precise Measurement of the G+C Content of Deoxyribonucleic Acid by High-Performance Liquid Chromatography

, 1989
M. Mesbah, U. Premachandran, W. Whitman
semanticscholar   +1 more source

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

The FEBS Journal, EarlyView.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi, Monica Cozzi, Somayeh Asgharpour, Omar De Bei, Serena Faggiano, Francesco Marchesani, Luca Ronda, Marialaura Marchetti, Eleonora Gianquinto, Mariacristina Failla, Gauthier Trèves, Loretta Lazzarato, Francesca Spyrakis, Barbara Campanini, Emanuela Frangipani, Stefano Bettati   +15 more
wiley   +1 more source

3'-<i>O</i>-β-Glucosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase. [PDF]

RSC Chem Biol
Dolan JP, Keenan T, Cheallaigh AN, Fascione MA, Miller GJ.   +4 more
europepmc   +1 more source

The association between HIV drug resistance testing, viral suppression and mortality in Ontario: a retrospective cohort study

HIV Medicine, EarlyView.
Abstract Background Drug resistance compromises the effectiveness of antiretroviral therapy (ART). Resistance testing prior to initiating therapy is recommended in guidelines in many high‐income countries, and it has been shown to improve outcomes after first‐line ART regimen failure. There is limited evidence on its role in treatment‐naïve individuals.
Lawrence Mbuagbaw, Carmen H. Logie, Lehana Thabane, Fiona Smaill, Marek Smieja, Ann N. Burchell, Beth Rachlis, Jean Eric Tarride, Abigail E. Kroch, Tony Mazzulli, Elizabeth Alvarez, Francis Nguyen, Richard Perez, Cristian Garcia, Jessyca Matos Silva, Hsien Seow   +15 more
wiley   +1 more source

Chemical reactivity of RNA and its modifications with hydrazine. [PDF]

Commun Chem
Yeşiltaç-Tosun N, Qi Y, Li C, Stafflinger H, Hollnagel K, Rusling L, Wöhnert J, Kaiser S, Kaiser S.   +8 more
europepmc   +1 more source

Transphosphorylation from Nucleoside Di- and Triphosphates by Apatite Crystals

, 1962
Stephen M. Krane, Melvin J. Glimcher
openalex   +1 more source