Results 291 to 300 of about 198,787 (385)

UCK2-dependent conversion of cytidine to CTP is required for CTP uptake by <i>Chlamydia trachomatis</i>. [PDF]

MicroPubl Biol
Blanchet L, Subtil A.
europepmc   +1 more source

The Metabolic Transition Between Fasting and Feeding Alters Aging‐Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans

Aging Cell, EarlyView.
In humans, prolonged fasting profoundly remodels the plasma metabolome while maintaining stable levels of BCAA and FGF21. Upon refeeding, plasma BCAAs (valine, isoleucine, and leucine) decline, reflecting tissue uptake and coinciding with a surge in FGF21, independent of insulin and glucose.
Maria Lastra Cagigas, Nancy T. Santiappillai, Serena Commissati, Giovanni Fiorito, Andrius Masedunskas, Gayathiri Rajakumar, Isabella de Ciutiis, Alan Goldhamer, Brian K. Kennedy, Andrew J. Hoy, Luigi Fontana   +10 more
wiley   +1 more source

Preparation of nucleoside analogues: opportunities for innovation at the interface of synthetic chemistry and biocatalysis. [PDF]

Chem Sci
Salihovic A, Taladriz-Sender A, Burley GA.   +2 more
europepmc   +1 more source

Studies on Nucleosides and Nucleotides. X. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. III. Reaction of 2', 3'-Di-O-tosyluridine with Methanolic Ammonia

, 1968
Miyoshi Hirata
openalex   +2 more sources

Hepatitis B Immunoglobulins Withdrawal in Hepatitis B Virus Mono‐Infected Liver Transplant Recipients: An Italian Multicentre Prospective Study

Alimentary Pharmacology &Therapeutics, EarlyView.
Hepatitis B immunoglobulins withdrawal in hepatitis B virus mono‐infected liver transplant recipients: An Italian multicentre prospective study. ABSTRACT Background & Aims Despite recommendations from scientific societies that hepatitis B immunoglobulin (HBIG) can be safely discontinued, centres across Europe continue to use the combination nucleoside ...
Raffaella Viganò, Alessandro Loglio, Clara Dibenedetto, Paola Carrai, Silvia Martini, Ilaria Lenci, Bianca Magro, Sara Conti, Paolo Angelo Cortesi, Chiara Mazzarelli, Chiara Becchetti, Giovanni Perricone, Monica Cucco, Marco Carbone, Donatella Cocchis, Elisa Farina, Luisa Pasulo, Mauro Viganò, Michele Sagasta, Elisabetta Degasperi, Davide Ghinolfi, Pietro Lampertico, Stefano Fagiuoli, Luca Saverio Belli, on behalf of the INSIGHT‐B study group   +24 more
wiley   +1 more source

The Site of Azido Substitution in a Pyrimidine Nucleobase Dictates the Type of Nitrogen-Centered Radical Formed after Dissociative Electron Attachment. [PDF]

J Phys Chem B
Adjei D, de Cabrera M, Reyes Y, Barbolovici A, Alahmadi M, Ward S, Menet MC, Mejanelle P, Kumar A, Sevilla MD, Wnuk SF, Mostafavi M, Adhikary A.   +12 more
europepmc   +1 more source

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Left: Cells with active SAMHD1 can metabolize cytarabine (ara‐C) and fludarabine (F‐ara‐A) to their inactive precursors, limiting their cytotoxic effects. Right: Addition of hydroxyurea (hydroxycarbamide; HU) inhibits SAMHD1, leading to an increase in the active metabolites of ara‐C and F‐ara‐A and a subsequent increase in the cytotoxicity of these ...
Ingrid Lilienthal, Sijia Tao, Christer Nilsson, Elory Leonard, Runqing Zhang, Agnes L. Sorteberg, Louisa Fredrikson, Ioanna Xagoraris, Shahrzad Shirazi Fard, Nikolaos Tsesmetzis, Vasilios Zachariadis, Huan Cai, Lakshmi Sandhow, Anette Langebäck, Anna Bohlin, Katja Pokrovskaja Tamm, Sofia Bengtzén, Raymond F. Schinazi, Sören Lehmann, Baek Kim, Georgios Z. Rassidakis, Hong Qian, Martin Jädersten, Nikolas Herold   +23 more
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine-Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions. [PDF]

Angew Chem Int Ed Engl
Huxley C, Fung E, Singh B, Caballero-García G, Muir G, Silverman SM, Campeau LC, Britton R.   +7 more
europepmc   +1 more source

Comprehensive Analysis of Small RNA Modifications in <i>Arabidopsis thaliana</i> and Their Dynamics During Seed Germination. [PDF]

Metabolites
Jiang LC, Men M, Cui XJ, Zeng RJ, Gu SY, Feng T, Zeng C, Ye T, Xiong J, Yuan BF, Feng YQ.   +10 more
europepmc   +1 more source

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source